PDF(Pubmed)
Abstract：
The anterior gradient protein 2 (AGR2) plays a crucial role in facilitating the formation of protein disulfide bonds within the endoplasmic reticulum (ER). Research suggests that AGR2 can function as an oncogene, with its heightened expression linked to the advancement of hepatobiliary and pancreatic cancers through invasion and metastasis. Notably, AGR2 not only serves as a pro-oncogenic agent but also as a downstream targeting protein, indirectly fostering cancer progression. This comprehensive review delves into the established functions and expression patterns of AGR2, emphasizing its pivotal role in cancer progression, particularly in hepatobiliary and pancreatic malignancies. Furthermore, AGR2 emerges as a potential cancer prognostic marker and a promising target for immunotherapy, offering novel avenues for the treatment of hepatobiliary and pancreatic cancers and enhancing patient outcomes.
摘要：
前梯度蛋白2（AGR2）在促进内质网（ER）内蛋白质二硫键的形成中起着至关重要的作用。研究表明AGR2可以作为癌基因发挥作用，它的高表达与肝胆和胰腺癌通过侵袭和转移的进展有关。值得注意的是,AGR2不仅是一种原癌基因，也是一种下游靶向蛋白。间接促进癌症进展。这篇全面的综述探讨了AGR2的功能和表达模式，强调了它在癌症进展中的关键作用。尤其是肝胆和胰腺恶性肿瘤。此外，AGR2成为潜在的癌症预后标志物和有希望的免疫治疗靶点。为肝胆和胰腺癌的治疗提供了新的途径，并提高了患者的预后。
