PDF(Pubmed)
Abstract：
Anthracyclines have significantly improved the survival of children with malignant tumors, but the associated cardiotoxicity, an effect now under the purview of pediatric cardio-oncology, due to its cumulative and irreversible effects on the heart, limits their clinical application. A systematic screening and risk stratification approach provides the opportunity for early identification and intervention to mitigate, reverse, or prevent myocardial injury, remodeling, and dysfunction associated with anthracyclines. This review summarizes the risk factors, surveillance indexes, and preventive strategies of anthracycline-related cardiotoxicity to improve the safety and efficacy of anthracyclines.
摘要：
蒽环类药物能显著提高儿童恶性肿瘤的生存率,但相关的心脏毒性,现在在儿科心脏肿瘤学的范围内，由于其对心脏的累积和不可逆转的影响，限制了其临床应用。系统的筛查和风险分层方法为早期识别和干预提供了机会，反向,或预防心肌损伤，重塑，以及与蒽环类药物相关的功能障碍。这篇综述总结了风险因素，监测指标,以及蒽环类药物相关心脏毒性的预防策略，以提高蒽环类药物的安全性和有效性。
