PDF(Pubmed)
Abstract：
This systematic review aims to investigate the relationship between muscle mass and specific health outcomes in pediatric populations with neuromuscular disorders. A search was performed for any relevant studies published in English from 1996 to 2023 in five databases. To be included in this analysis, articles must have had participants with an average age ≤21, focus on children with neuromuscular disabilities, and primarily examine relationships between muscle mass and any functional or health outcomes measure. Studies including typically developing children were used to contrast and enhance findings. Thirty-two studies were included, with 10,129 unique individuals represented: seventeen studies focused on healthy/typically developing children; seven on children with cerebral palsy; three on children with Duchenne muscular dystrophy; two on children with sarcopenia; and one study each on children with osteoporosis, congenital muscular dystrophy, and other various neurologic disorders. Thirteen studies assessed functional outcomes, ten assessed bone outcomes, and nine assessed other cardiovascular/metabolic outcomes. All of the included studies demonstrated relationships between muscle mass and respective outcomes in varying measures. The results of this review demonstrate that there is a consistently recognized relationship between muscle mass and important health outcomes in children, supporting clinically targeting muscle mass as a means to optimize desired outcomes.
摘要：
本系统评价旨在研究患有神经肌肉疾病的儿科人群中肌肉质量与特定健康结局之间的关系。在五个数据库中搜索了1996年至2023年以英文发表的任何相关研究。要包括在此分析中，文章必须有平均年龄≤21岁的参与者，重点关注神经肌肉残疾儿童，并主要检查肌肉质量与任何功能或健康结果之间的关系。包括典型发育中的儿童在内的研究被用来对比和增强研究结果。包括32项研究，有10,129个独特的个体代表:17项研究集中在健康/典型发育儿童;7项关于脑瘫儿童;3项关于Duchenne肌营养不良儿童;2项关于肌肉减少症儿童;和1项关于骨质疏松症儿童的研究,先天性肌营养不良,和其他各种神经系统疾病。13项研究评估了功能结果，十项评估的骨骼结果，9项评估了其他心血管/代谢结果。所有纳入的研究都以不同的措施证明了肌肉质量与各自结果之间的关系。这篇综述的结果表明，在儿童中，肌肉质量和重要的健康结果之间存在一致公认的关系。支持临床靶向肌肉质量作为优化预期结果的手段。
