PDF(Pubmed)
Abstract：
Treating depression in adolescents is a significant challenge, and major depressive disorder (MDD) with suicidal ideation and treatment-resistant depression (TRD) are common and potentially devastating to optimal psychological and physical development in this age group. Suicide is among the leading causes of youth mortality, and TRD occurs in up to 40% of adolescents with MDD. TRD involves severe, persistent symptoms that are hard to treat, significantly reducing functioning and quality of life. We conducted a literature search focusing on key terms related to ketamine and esketamine for MDD with suicidal ideation and TRD in adolescents, aiming to review the potential utility of these molecules in adolescents for these conditions. Ketamine has shown efficacy in reducing depressive symptoms in adolescents with TRD. Esketamine has shown efficacy in reducing depressive symptoms and treating suicidal ideation in adolescents. Both ketamine and esketamine have demonstrated favorable safety and tolerability profiles. Using these drugs for serious conditions like adolescent MDD with suicidal thoughts and TRD can effectively treat symptoms, reduce self-harm and suicide risks, and provide a window for longer-term therapeutic interventions. The prompt and effective treatment of TRD could improve adolescents\' quality of life. However, more research is needed to optimize treatment protocols and evaluate long-term effects.
摘要：
治疗青少年抑郁症是一项重大挑战，重度抑郁症(MDD)伴自杀意念和难治性抑郁症(TRD)在这一年龄组中很常见,并可能对最佳心理和身体发育造成破坏.自杀是青年死亡的主要原因之一，和TRD发生在多达40％的青少年MDD。TRD涉及严重，难以治疗的持续症状，显著降低功能和生活质量。我们进行了文献检索，重点关注与氯胺酮和艾氯胺酮治疗青少年自杀意念和TRD的MDD相关的关键术语。旨在回顾这些分子在青少年中对这些疾病的潜在效用。氯胺酮已显示出减轻TRD青少年抑郁症状的功效。Esketamine已显示出减轻青少年抑郁症状和治疗自杀意念的功效。氯胺酮和艾氯胺酮都表现出良好的安全性和耐受性。使用这些药物治疗青少年MDD伴自杀念头和TRD等严重疾病可以有效治疗症状，减少自我伤害和自杀风险，并为长期治疗干预提供了一个窗口。及时有效的TRD治疗可以改善青少年的生活质量。然而,需要更多的研究来优化治疗方案和评估长期效果.
