PDF(Pubmed)
Abstract：
(1) Background: Multiple sclerosis (MS) is a chronic, complex, and demyelinating disease closely associated with altered levels of trace elements. Although the first studies into the role of trace elements in MS were published in the 1970s, for five decades it has remained unknown whether trace elements can be part of this heterogeneous neurological disease. (2) Materials and methods: To drive toward at a potential solution, we conducted a systematic review and meta-analysis to elucidate whether there were differences in circulating levels of neurologically important essential trace elements (Zn, Fe, Co, Cu, Mn, and Se) between MS cases and controls. (3) Results: This study revealed significantly lower serum/plasma Zn and Fe levels and higher Cu levels in MS-affected individuals compared to controls. At the same time, no significant differences were found between the MS cases and controls regarding their serum/plasma levels of Co, Mn, or Se. Thus, the loss of Fe and Zn should be considered in supplementation/nutrition strategies for MS patients. On the other hand, since high serum Cu levels indicate a burden on the bloodstreams of MS patients, Cu should be excluded from mineral supplement strategies. Furthermore, all three trace elements (Fe, Zn, and Cu) should be considered from an etiological point of view, and, most importantly, their levels in the bloodstreams of MS patients should be monitored. (4) Conclusions: This study highlights the way for personalized and targeted strategies in the management of MS.
摘要：
(1)背景:多发性硬化症(MS)是一种慢性,复杂，脱髓鞘疾病与微量元素水平的改变密切相关。尽管关于微量元素在MS中的作用的第一个研究发表在20世纪70年代，五十年来，人们一直不知道微量元素是否可以成为这种异质性神经系统疾病的一部分。(2)材料和方法：为了朝着潜在的解决方案前进，我们进行了系统评价和荟萃分析，以阐明神经重要的必需微量元素的循环水平是否存在差异（锌，Fe,Co,Cu,Mn,和Se）在MS病例和对照之间。(3)结果:与对照组相比,该研究揭示了受MS影响的个体中显著较低的血清/血浆Zn和Fe水平和较高的Cu水平。同时,MS病例和对照组之间的血清/血浆Co水平没有发现显着差异，Mn,或者Se。因此，在MS患者的补充/营养策略中应考虑铁和锌的损失.另一方面,由于高血清Cu水平表明MS患者的血液负担，铜应该从矿物质补充策略中排除。此外，所有三种微量元素(Fe，Zn,和铜)应从病因学的角度考虑，and,最重要的是,应监测其在MS患者血流中的水平.（4）结论：本研究强调了在MS管理中个性化和针对性策略的途径。
