PDF(Pubmed)
Abstract：
Environmental pollutants have been linked to neurotoxicity and are proposed to contribute to neurodegenerative disorders. The zebrafish model provides a high-throughput platform for large-scale chemical screening and toxicity assessment and is widely accepted as an important animal model for the investigation of neurodegenerative disorders. Although recent studies explore the roles of environmental pollutants in neurodegenerative disorders in zebrafish models, current knowledge of the mechanisms of environmentally induced neurodegenerative disorders is relatively complex and overlapping. This review primarily discusses utilizing embryonic zebrafish as the model to investigate environmental pollutants-related neurodegenerative disease. We also review current applicable approaches and important biomarkers to unravel the underlying mechanism of environmentally related neurodegenerative disorders. We found embryonic zebrafish to be a powerful tool that provides a platform for evaluating neurotoxicity triggered by environmentally relevant concentrations of neurotoxic compounds. Additionally, using variable approaches to assess neurotoxicity in the embryonic zebrafish allows researchers to have insights into the complex interaction between environmental pollutants and neurodegenerative disorders and, ultimately, an understanding of the underlying mechanisms related to environmental toxicants.
摘要：
环境污染物与神经毒性有关，并被认为有助于神经退行性疾病。斑马鱼模型为大规模化学筛选和毒性评估提供了高通量平台，被广泛认为是研究神经退行性疾病的重要动物模型。尽管最近的研究探索了环境污染物在斑马鱼模型中神经退行性疾病中的作用，目前对环境诱导的神经退行性疾病机制的认识相对复杂和重叠。这篇综述主要讨论了利用胚胎斑马鱼作为模型来研究环境污染物相关的神经退行性疾病。我们还回顾了当前适用的方法和重要的生物标志物，以揭示与环境相关的神经退行性疾病的潜在机制。我们发现胚胎斑马鱼是一种强大的工具，为评估由环境相关浓度的神经毒性化合物引发的神经毒性提供了平台。此外,使用可变方法来评估胚胎斑马鱼的神经毒性使研究人员能够深入了解环境污染物和神经退行性疾病之间的复杂相互作用，最终,了解与环境毒物相关的潜在机制。
