PDF(Pubmed)
Abstract：
Quinoa, a globally cultivated \"golden grain\" belonging to Chenopodium in the Amaranthaceae family, is recognized for being gluten-free, with a balanced amino acid profile and multiple bioactive components, including peptides, polysaccharides, polyphenols, and saponins. The bioactive compounds extracted from quinoa offer multifaceted health benefits, including antioxidative, anti-inflammatory, antimicrobial, cardiovascular disease (CVD) improvement, gut microbiota regulation, and anti-cancer effects. This review aims to intricately outline quinoa\'s nutritional value, functional components, and physiological benefits. Importantly, we comprehensively provide conclusions on the effects and mechanisms of these quinoa-derived bioactive components on multiple cancer types, revealing the potential of quinoa seeds as promising and effective anti-cancer agents. Furthermore, the health-promoting role of quinoa in modulating gut microbiota, maintaining gut homeostasis, and protecting intestinal integrity was specifically emphasized. Finally, we provided a forward-looking description of the opportunities and challenges for the future exploration of quinoa. However, in-depth studies of molecular targets and clinical trials are warranted to fully understand the bioavailability and therapeutic application of quinoa-derived compounds, especially in cancer treatment and gut microbiota regulation. This review sheds light on the prospect of developing dietary quinoa into functional foods or drugs to prevent and manage human diseases.
摘要：
藜麦,一种全球栽培的“黄金谷物”，属于a科的藜属，被认为是无麸质的，具有平衡的氨基酸谱和多种生物活性成分，包括肽，多糖，多酚，和皂苷。从藜麦提取的生物活性化合物提供多方面的健康益处，包括抗氧化，抗炎,抗菌，心血管疾病（CVD）改善，肠道微生物群调节，和抗癌作用。这篇综述旨在错综复杂地概述藜麦的营养价值，功能部件,和生理益处。重要的是,我们全面提供了这些藜麦衍生的生物活性成分对多种癌症类型的影响和机制的结论，揭示了藜麦种子作为有前途和有效的抗癌药物的潜力。此外，藜麦在调节肠道微生物群中的健康促进作用，保持肠道稳态，并特别强调保护肠道完整性。最后,我们对藜麦未来勘探的机遇和挑战进行了前瞻性描述。然而,有必要对分子靶标和临床试验进行深入研究，以充分了解藜麦衍生化合物的生物利用度和治疗应用，特别是在癌症治疗和肠道菌群调节方面。这篇综述揭示了将膳食藜麦开发成功能性食品或药物以预防和管理人类疾病的前景。
