PDF(Pubmed)
Abstract：
Non-alcoholic fatty liver disease (NAFLD) is a global public health problem that causes liver-related morbidity and mortality. It is also an independent risk factor for non-communicable diseases. In 2020, a proposal was made to refer to it as \"metabolic dysfunction-associated fatty liver disease (MAFLD)\", with concise diagnostic criteria. Given its widespread occurrence, its treatment is crucial. Increased levels of oxidative stress cause this disease. This review aims to evaluate various studies on antioxidant therapies for patients with MAFLD. A comprehensive search for relevant research was conducted on the PubMed, SCOPUS, and ScienceDirect databases, resulting in the identification of 87 studies that met the inclusion criteria. In total, 31.1% of human studies used natural antioxidants, 53.3% used synthetic antioxidants, and 15.5% used both natural and synthetic antioxidants. In human-based studies, natural antioxidants showed 100% efficacy in the treatment of MAFLD, while synthetic antioxidants showed effective results in only 91% of the investigations. In animal-based research, natural antioxidants were fully effective in the treatment of MAFLD, while synthetic antioxidants demonstrated effectiveness in only 87.8% of the evaluations. In conclusion, antioxidants in their natural form are more helpful for patients with MAFLD, and preserving the correct balance of pro-oxidants and antioxidants is a useful way to monitor antioxidant treatment.
摘要：
非酒精性脂肪性肝病（NAFLD）是导致肝脏相关发病率和死亡率的全球性公共卫生问题。它也是非传染性疾病的独立危险因素。2020年，有人提议将其称为“代谢功能障碍相关的脂肪肝疾病（MAFLD）”，用简明的诊断标准。鉴于它的广泛发生，它的治疗至关重要。氧化应激水平的增加导致这种疾病。这篇综述旨在评估MAFLD患者抗氧化疗法的各种研究。在PubMed上进行了相关研究的全面搜索，Scopus,和ScienceDirect数据库，结果确定了87项符合纳入标准的研究。总的来说,31.1％的人体研究使用天然抗氧化剂，53.3%使用合成抗氧化剂，15.5%使用天然和合成抗氧化剂。在基于人类的研究中，天然抗氧化剂在MAFLD的治疗中显示出100％的功效，而合成抗氧化剂在只有91%的调查中显示出有效的结果。在基于动物的研究中，天然抗氧化剂在MAFLD的治疗中完全有效，而合成抗氧化剂仅在87.8%的评价中表现出有效性。总之,天然形式的抗氧化剂对MAFLD患者更有帮助，保持促氧化剂和抗氧化剂的正确平衡是监测抗氧化剂治疗的有用方法。
