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Abstract：
The radiomic analysis of the tissue surrounding colorectal liver metastases (CRLM) enhances the prediction accuracy of pathology data and survival. We explored the variation of the textural features in the peritumoural tissue as the distance from CRLM increases. We considered patients with hypodense CRLMs >10 mm and high-quality computed tomography (CT). In the portal phase, we segmented (1) the tumour, (2) a series of concentric rims at a progressively increasing distance from CRLM (from one to ten millimetres), and (3) a cylinder of normal parenchyma (Liver-VOI). Sixty-three CRLMs in 51 patients were analysed. Median peritumoural HU values were similar to Liver-VOI, except for the first millimetre around the CRLM. Entropy progressively decreased (from 3.11 of CRLM to 2.54 of Liver-VOI), while uniformity increased (from 0.135 to 0.199, p < 0.001). At 10 mm from CRLM, entropy was similar to the Liver-VOI in 62% of cases and uniformity in 46%. In small CRLMs (≤30 mm) and responders to chemotherapy, normalisation of entropy and uniformity values occurred in a higher proportion of cases and at a shorter distance. The radiomic analysis of the parenchyma surrounding CRLMs unveiled a wide halo of progressively decreasing entropy and increasing uniformity despite a normal radiological aspect. Underlying pathology data should be investigated.
摘要：
结直肠癌肝转移灶（CRLM）周围组织的影像组学分析提高了病理数据和生存率的预测准确性。我们探索了随着与CRLM的距离增加，肿瘤周围组织中纹理特征的变化。我们考虑了低密度CRLM>10mm和高质量计算机断层扫描（CT）的患者。在门户阶段，我们分割（1）肿瘤，（2）与CRLM的距离逐渐增加（从1毫米到10毫米）的一系列同心轮辋，和(3)正常实质的圆柱体(肝脏-VOI)。分析了51例患者的63例CRLM。腔周HU中位数与肝脏VOI相似，除了CRLM周围的第一个毫米。熵逐渐降低（从CRLM的3.11到肝脏VOI的2.54），而均匀度增加（从0.135增加到0.199，p<0.001）。距离CRLM10毫米处，在62%的病例中,熵与肝脏-VOI相似,在46%的病例中,熵与肝脏-VOI相似。在小CRLM（≤30mm）和化疗应答者中，熵值和均匀度值的归一化发生在较高比例的情况下，并且距离较短。尽管放射学方面正常，但对CRLM周围薄壁组织的放射学分析揭示了熵逐渐降低和均匀性增加的广泛光环。应调查基础病理数据。
