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Abstract：
The aim of this study was to compare vessel density (VD) in the retina and choroid in eyes with primary open angle glaucoma (POAG), normal tension glaucoma (NTG) and controls. Patients with POAG, NTG and controls underwent OCT scanning of the macula and the disc followed by 6 × 6 mm macula OCT angiography (OCTA) imaging. Global and hemifield VD were recorded for the superficial (SVP) and deep (DVP) vascular plexus and the choriocapillaris (CC). The OCT thickness of the nerve fiber layer (NFL) and ganglion cell layer (GCC) was also measured. Data from 65 POAG, 33 NTG and 40 control eyes matched for age were analyzed. Mean SVP VD was lower in NTG and POAG eyes compared to controls (38.8 ± 5.3, 40.7 ± 6.8 and 48.5 ± 4.0%, p < 0.001). Mean DVP VD was lower in NTG and POAG eyes compared to controls (43.1 ± 6.1, 44.5 ± 7.6 and 48.6 ± 5.8%, p = 0.002). There was no difference in SVP VD or DVP VD between the glaucoma groups (p > 0.050). No difference was noted in CC VD between the groups (68.3 ± 2.3, 67.6 ± 3.7 and 68.5 ± 2.6%, p = 0.287). Lower SVP and DVP VD was seen in eyes with glaucoma compared to normal eyes. NTG and POAG eyes had similar VD loss. Eyes with glaucoma manifested similar CC VD compared to controls.
摘要：
这项研究的目的是比较原发性开角型青光眼（POAG）的视网膜和脉络膜的血管密度（VD）。正常眼压性青光眼（NTG）和对照。POAG患者,NTG和对照组接受黄斑和椎间盘的OCT扫描，然后进行6×6mm黄斑OCT血管造影（OCTA）成像。记录了浅表（SVP）和深层（DVP）血管丛和脉络膜毛细血管（CC）的全局和偏场VD。还测量了神经纤维层(NFL)和神经节细胞层(GCC)的OCT厚度。数据来自65POAG，分析了33只NTG和40只年龄匹配的对照眼。与对照组相比，NTG和POAG眼的平均SVPVD较低（38.8±5.3，40.7±6.8和48.5±4.0％，p<0.001)。与对照组相比，NTG和POAG眼的平均DVPVD较低（43.1±6.1、44.5±7.6和48.6±5.8％，p=0.002)。青光眼组之间的SVPVD或DVPVD没有差异（p>0.050）。两组之间的CCVD无差异（68.3±2.3，67.6±3.7和68.5±2.6％，p=0.287）。与正常眼相比，青光眼眼中的SVP和DVPVD较低。NTG和POAG眼有相似的VD损失。与对照组相比，青光眼的眼睛表现出相似的CCVD。
