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Abstract：
Serum and urinary uromodulin are evaluated as potential biomarkers of kidney disease. The aim of our research was to select a more appropriate form of uromodulin for the diagnosis of early stages of chronic kidney disease (CKD). We also focused on the influence of age and gender in one breed on uromodulin and on the possible interbreed differences. Serum uromodulin had the lowest values in dogs younger than 2 years but no effect of gender, breed, or CKD was observed. Urinary uromodulin indexed to urinary creatinine was significantly reduced in dogs in stage 2 of CKD (p = 0.003) in contrast to uromodulin converted to urine specific gravity. Urinary uromodulin with both corrections was significantly lower in Belgian shepherds compared to German shepherds (p < 0.0001, p = 0.0054) but was not influenced by gender or age. In stage 1 of CKD, urinary uromodulin correlated with kidney disease markers SDMA (p = 0.0424, p = 0.0214) and UPC (p = 0.0050, p = 0.0024). Urinary uromodulin appears to be more associated with CKD than serum uromodulin. Further studies with a larger number of patients are needed for the suitability of urinary uromodulin as a marker of early-stage disease.
摘要：
血清和尿调节素被评估为肾脏疾病的潜在生物标志物。我们研究的目的是选择更合适的尿调节素形式来诊断慢性肾脏疾病（CKD）的早期阶段。我们还重点研究了一个品种的年龄和性别对尿调蛋白的影响以及可能的品种间差异。在2岁以下的狗中，血清尿调节素的值最低，但性别没有影响，品种,或观察到CKD。与尿调节蛋白转化为尿比重相比，CKD第2阶段犬的尿尿调节蛋白显着降低（p=0.003）。与德国牧羊犬相比，比利时牧羊犬的尿路调节素均显着降低（p<0.0001，p=0.0054），但不受性别或年龄的影响。在CKD的第一阶段，尿调节蛋白与肾脏疾病标志物SDMA(p=0.0424,p=0.0214)和UPC(p=0.0050,p=0.0024)相关。尿路调节素似乎比血清尿路调节素更与CKD相关。对于尿路调节素作为早期疾病标志物的适用性，需要对更多患者进行进一步研究。
