PDF(Pubmed)
Abstract：
Recent evidence suggests a connection between hyperacusis and the motor system of the brain. For instance, our recent study reported that hyperacusis in participants with tinnitus and hearing loss is associated with smaller gray matter volumes in the supplementary motor area (SMA). Given that hearing loss can affect gray matter changes in tinnitus, this study aimed to determine if the changes reported in our previous findings of smaller SMA gray matter volumes in hyperacusis persist in the absence of hearing loss. Data for this study were gathered from four prior studies conducted between 2004 and 2019 at the University Medical Centre Groningen (UMCG). A total of 101 participants with tinnitus and either clinically normal hearing (normal hearing with tinnitus or NHT, n = 35) or bilateral sensorineural hearing loss (hearing loss with tinnitus or HLT, n = 66) were included across four studies. Hyperacusis was determined by a score of ≥22 on the Hyperacusis Questionnaire (HQ). In the NHT group, 22 (63%) participants scored ≥22 on the HQ (NHT with hyperacusis: mean age 44.1 years, 12 females), while in the HLT group, 25 (38%) participants scored ≥22 on the HQ (HLT with hyperacusis: mean age 59.5 years, 10 females). The 2 × 2 between-group ANOVAs revealed that hyperacusis is associated with smaller SMA gray matter volumes, regardless of hearing levels. Notably, the smaller SMA gray matter volumes in hyperacusis were primarily influenced by the attentional subscales of the HQ. The association between hyperacusis and the motor system may indicate a constant alertness to sounds and a readiness for motor action.
摘要：
最近的证据表明，运动过度与大脑的运动系统之间存在联系。例如,我们最近的研究报告,耳鸣和听力损失参与者的运动过度与辅助运动区(SMA)较小的灰质体积相关.鉴于听力损失会影响耳鸣的灰质变化，本研究旨在确定在没有听力损失的情况下,我们之前的研究结果中所报告的较小SMA灰质体积的变化是否持续.这项研究的数据来自2004年至2019年在格罗宁根大学医学中心（UMCG）进行的四项先前研究。共有101名患有耳鸣和临床正常听力（耳鸣或NHT的正常听力，n=35）或双侧感音神经性听力损失（耳鸣或HLT的听力损失，n=66)被纳入四项研究。高音通过高音量表（HQ）评分≥22来确定。在NHT组中，22名（63%）参与者在总部得分≥22（NHT伴过度发作：平均年龄44.1岁，12名女性），而在HLT组,25（38％）的参与者在HQ上得分≥22（HLT伴运动过度：平均年龄59.5岁，10名女性）。2×2组间方差分析显示，运动过度与较小的SMA灰质体积有关，无论听力水平如何。值得注意的是,高音区较小的SMA灰质体积主要受HQ注意分量表的影响。超触觉和运动系统之间的关联可以指示对声音的持续警觉性和对运动动作的准备。
