青蒿琥酯通过靶向 Ido1 诱导黑色素瘤细胞铁凋亡并增强抗肿瘤免疫力。
关键词: Artesunate CD8+ T cell Ferroptosis Ido1 Melanoma
Mesh : Indoleamine-Pyrrole 2,3,-Dioxygenase / metabolism genetics Ferroptosis / drug effects Animals Artesunate / pharmacology therapeutic use Melanoma / drug therapy pathology Mice Cell Line, Tumor Humans Mice, Inbred C57BL CD8-Positive T-Lymphocytes / drug effects immunology Cell Proliferation / drug effects Heme Oxygenase-1 / metabolism genetics
来 源:
DOI:10.1186/s12964-024-01759-8
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