Abstract:
The primary sensory neurons involved in pain perception express various types of receptor-type ion channels at their nerve endings. These molecules are responsible for triggering neuronal excitation, translating environmental stimuli into pain signals. Recent studies have shown that acute nociception, induced by neuronal excitation, not only serves as a sensor for signaling life-threatening situations but also modulates our pathophysiological conditions. This modulation occurs through the release of neuropeptides by primary sensory neurons excited by nociceptive stimuli, which directly or indirectly affect peripheral systems, including immune function. Senso-immunology, an emerging research field, integrates interdisciplinary studies of pain and immunology and has garnered increasing attention in recent years. This review provides an overview of the systemic pathophysiological functions regulated by receptor-type ion channels, such as transient receptor potential (TRP) channels in primary sensory neurons, from the perspective of senso-immunology.
摘要:
参与疼痛感知的初级感觉神经元在其神经末梢表达各种类型的受体型离子通道。这些分子负责触发神经元兴奋,将环境刺激转化为疼痛信号。最近的研究表明,急性伤害感受,由神经元兴奋诱导,不仅作为信号威胁生命的情况的传感器,而且还调节我们的病理生理条件。这种调节是通过由伤害性刺激激发的初级感觉神经元释放神经肽而发生的。直接或间接影响外围系统,包括免疫功能。Senso-免疫学,一个新兴的研究领域,整合了疼痛和免疫学的跨学科研究,近年来引起了越来越多的关注。本文综述了受体型离子通道调节的全身病理生理功能。例如初级感觉神经元中的瞬时受体电位(TRP)通道,从感官免疫学的角度来看。