Abstract：
OBJECTIVE: Resection of brain metastases is a well-established treatment modality that can prolong the survival of patients for whom surgery is indicated. Whole-brain radiotherapy (WBRT) has been the standard postoperative therapy. In recent years, however, clinicians have increasingly avoided WBRT due to its associated adverse events. This study investigated the impact of postoperative WBRT and systemic chemotherapy as prognostic factors on the survival of patients who had undergone resection of brain metastases.
METHODS: The study subjects were 172 patients who underwent surgical resection for brain metastases. Comparative analyses of survival after WBRT and systemic chemotherapy were performed.
RESULTS: Postoperative WBRT had no survival-prolonging effect, whereas postoperative systemic chemotherapy prolonged survival. A comparison based on the number of systemic chemotherapy regimens administered prior to surgery showed that fewer regimens correlated with a better prognosis.
CONCLUSIONS: The addition of WBRT after surgical resection of brain metastases is no longer a standard treatment strategy and systemic chemotherapy after surgery is a positive prognostic factor.
METHODS: The study subjects were 172 patients who underwent surgical resection for brain metastases. Comparative analyses of survival after WBRT and systemic chemotherapy were performed.
RESULTS: Postoperative WBRT had no survival-prolonging effect, whereas postoperative systemic chemotherapy prolonged survival. A comparison based on the number of systemic chemotherapy regimens administered prior to surgery showed that fewer regimens correlated with a better prognosis.
CONCLUSIONS: The addition of WBRT after surgical resection of brain metastases is no longer a standard treatment strategy and systemic chemotherapy after surgery is a positive prognostic factor.
摘要：
目的：脑转移瘤切除术是一种完善的治疗方式，可以延长需要手术治疗的患者的生存期。全脑放疗（WBRT）已成为标准的术后治疗方法。近年来,然而,由于WBRT相关的不良事件,临床医生越来越多地避免使用WBRT.这项研究调查了术后WBRT和全身化疗作为预后因素对脑转移瘤切除术患者生存率的影响。
方法：研究对象是172例因脑转移而接受手术切除的患者。对WBRT和全身化疗后的生存率进行了比较分析。
结果：术后WBRT没有延长生存的作用，而术后全身化疗延长生存期。基于手术前给予的全身化疗方案数量的比较表明，较少的方案与更好的预后相关。
结论：脑转移瘤手术切除后加用WBRT不再是标准的治疗策略，术后全身化疗是一个积极的预后因素。
方法：研究对象是172例因脑转移而接受手术切除的患者。对WBRT和全身化疗后的生存率进行了比较分析。
结果：术后WBRT没有延长生存的作用，而术后全身化疗延长生存期。基于手术前给予的全身化疗方案数量的比较表明，较少的方案与更好的预后相关。
结论：脑转移瘤手术切除后加用WBRT不再是标准的治疗策略，术后全身化疗是一个积极的预后因素。
