METHODS: The study subjects were 172 patients who underwent surgical resection for brain metastases. Comparative analyses of survival after WBRT and systemic chemotherapy were performed.
RESULTS: Postoperative WBRT had no survival-prolonging effect, whereas postoperative systemic chemotherapy prolonged survival. A comparison based on the number of systemic chemotherapy regimens administered prior to surgery showed that fewer regimens correlated with a better prognosis.
CONCLUSIONS: The addition of WBRT after surgical resection of brain metastases is no longer a standard treatment strategy and systemic chemotherapy after surgery is a positive prognostic factor.
方法:研究对象是172例因脑转移而接受手术切除的患者。对WBRT和全身化疗后的生存率进行了比较分析。
结果:术后WBRT没有延长生存的作用,而术后全身化疗延长生存期。基于手术前给予的全身化疗方案数量的比较表明,较少的方案与更好的预后相关。
结论:脑转移瘤手术切除后加用WBRT不再是标准的治疗策略,术后全身化疗是一个积极的预后因素。