Abstract：
OBJECTIVE: Neskeep®, an absorbable polyglycolic acid spacer, has been developed as the optimal material for spacer placement surgery. However, preventing its severe adhesion is a crucial concern. Therefore, we aimed to identify an effective anti-adhesion agent for Neskeep® using rat models.
METHODS: Animal experiments were performed using 60 rats, which underwent Neskeep® placement on the abdominal wall. Three types of anti-adhesion agents were employed, establishing four subgroups: Seprafilm®, INTERCEED®, AdSpray®, and only Neskeep® (control) groups. Rats were sacrificed on postoperative days 7, 14, and 28 to assess adhesion levels around the Neskeep® Macroscopic visual assessment with the Lauder score and histopathological evaluation were performed to assess the degree of adhesion.
RESULTS: There were no significant differences in the proportion of Lauder scores on days 7 and 14 between the four groups. Histological evaluation revealed no significant differences between groups at any observation time. However, the mean Lauder scores at day 28 were 5.0, 1.6, 4.0, and 4.8 in the Neskeep®, Seprafilm®, INTERCEED®, and AdSpray® groups, respectively. The proportion of milder Lauder score was significantly higher in the Seprafilm® group on day 28.
CONCLUSIONS: Seprafilm® may exhibit an anti-adhesive effect when used with Neskeep®.
METHODS: Animal experiments were performed using 60 rats, which underwent Neskeep® placement on the abdominal wall. Three types of anti-adhesion agents were employed, establishing four subgroups: Seprafilm®, INTERCEED®, AdSpray®, and only Neskeep® (control) groups. Rats were sacrificed on postoperative days 7, 14, and 28 to assess adhesion levels around the Neskeep® Macroscopic visual assessment with the Lauder score and histopathological evaluation were performed to assess the degree of adhesion.
RESULTS: There were no significant differences in the proportion of Lauder scores on days 7 and 14 between the four groups. Histological evaluation revealed no significant differences between groups at any observation time. However, the mean Lauder scores at day 28 were 5.0, 1.6, 4.0, and 4.8 in the Neskeep®, Seprafilm®, INTERCEED®, and AdSpray® groups, respectively. The proportion of milder Lauder score was significantly higher in the Seprafilm® group on day 28.
CONCLUSIONS: Seprafilm® may exhibit an anti-adhesive effect when used with Neskeep®.
摘要：
目标：Neskeep®，可吸收的聚乙醇酸垫片，已被开发为垫片放置手术的最佳材料。然而,防止其严重粘连是一个至关重要的问题。因此,我们旨在使用大鼠模型确定Neskeep®的有效抗粘连剂。
方法：使用60只大鼠进行动物实验，在腹壁上放置Neskeep®。使用了三种类型的抗粘连剂，建立四个亚组：Seprafilm®，INTERCEED®,AdSpray®,只有Neskeep®（对照）组。在术后第7、14和28天处死大鼠以评估Neskeep®周围的粘连水平具有Lauder评分的宏观视觉评估和组织病理学评估以评估粘连程度。
结果：四组之间在第7天和第14天的劳德评分比例没有显着差异。组织学评估显示在任何观察时间组间没有显著差异。然而,在Neskeep®中，Lauder在第28天的平均得分分别为5.0、1.6、4.0和4.8，Seprafilm®,INTERCEED®,和AdSpray®组，分别。在第28天,Seprafilm®组中温和劳德评分的比例显著较高。
结论：Seprafilm®与Neskeep®一起使用时可能表现出抗粘附作用。
方法：使用60只大鼠进行动物实验，在腹壁上放置Neskeep®。使用了三种类型的抗粘连剂，建立四个亚组：Seprafilm®，INTERCEED®,AdSpray®,只有Neskeep®（对照）组。在术后第7、14和28天处死大鼠以评估Neskeep®周围的粘连水平具有Lauder评分的宏观视觉评估和组织病理学评估以评估粘连程度。
结果：四组之间在第7天和第14天的劳德评分比例没有显着差异。组织学评估显示在任何观察时间组间没有显著差异。然而,在Neskeep®中，Lauder在第28天的平均得分分别为5.0、1.6、4.0和4.8，Seprafilm®,INTERCEED®,和AdSpray®组，分别。在第28天,Seprafilm®组中温和劳德评分的比例显著较高。
结论：Seprafilm®与Neskeep®一起使用时可能表现出抗粘附作用。
