PDF(Pubmed)
Abstract：
BACKGROUND: One of the topics that show differences of opinion in the scientific field of nutrition is the recommendation by clinical practice guidelines (CPGs) of an immunomodulatory diet with arginine, nucleotides and omega-3 for individuals diagnosed with cancer undergoing major surgery. The quality of the recommendations is directly related to credibility, transparency and rigour in their development, but also to the quality of the studies published and available for inclusion in the recommendation, such as systematic reviews (SRs) and randomised clinical trials. The aim of this study is to evaluate the methodological quality of the recommendation of perioperative immunomodulatory supplementation for individuals with gastrointestinal and head and neck cancer, the CPGs, and the studies that support the recommendations.
METHODS: We will conduct a systematic search for CPGs. Recommendations for nutritional supplementation with immunomodulatory substrates for individuals undergoing major oncological surgery will be analysed using the Appraisal of Guidelines Research and Evaluation-Recommendations Excellence tool. CPGs will be analysed using the Appraisal of Guidelines Research and Evaluation II tool. The SRs cited in the recommendations will be analysed using the A Measurement Tool to Assess Systematic Reviews II tool and additional questions regarding heterogeneity in reviews. The clinical trials cited in the SRs and in the guideline recommendations (when applicable) will be analysed according to questions regarding heterogeneity in trials. The results will be presented in tables or charts using descriptive analyses.
BACKGROUND: The results of this study will be disseminated through relevant conferences and peer-reviewed journals.
UNASSIGNED: 10.17605/OSF.IO/X2GYT.
METHODS: We will conduct a systematic search for CPGs. Recommendations for nutritional supplementation with immunomodulatory substrates for individuals undergoing major oncological surgery will be analysed using the Appraisal of Guidelines Research and Evaluation-Recommendations Excellence tool. CPGs will be analysed using the Appraisal of Guidelines Research and Evaluation II tool. The SRs cited in the recommendations will be analysed using the A Measurement Tool to Assess Systematic Reviews II tool and additional questions regarding heterogeneity in reviews. The clinical trials cited in the SRs and in the guideline recommendations (when applicable) will be analysed according to questions regarding heterogeneity in trials. The results will be presented in tables or charts using descriptive analyses.
BACKGROUND: The results of this study will be disseminated through relevant conferences and peer-reviewed journals.
UNASSIGNED: 10.17605/OSF.IO/X2GYT.
摘要：
背景：在营养科学领域显示意见分歧的主题之一是临床实践指南（CPGs）对精氨酸免疫调节饮食的建议，核苷酸和omega-3用于诊断患有癌症的个体接受大手术。建议的质量直接关系到可信度,他们发展的透明度和严谨性，以及已发表和可纳入建议的研究的质量，如系统评价(SRs)和随机临床试验。这项研究的目的是评估胃肠道和头颈部癌症患者围手术期免疫调节补充建议的方法学质量，CPGs,以及支持这些建议的研究。
方法：我们将对CPG进行系统的搜索。将使用“评估指南研究和评估-推荐卓越”工具分析接受大型肿瘤手术的个体的免疫调节底物营养补充建议。将使用评估准则研究和评估II工具对CPG进行分析。建议中引用的SR将使用评估系统审查的衡量工具II工具和有关审查异质性的其他问题进行分析。SRs和指南建议（适用时）中引用的临床试验将根据有关试验异质性的问题进行分析。结果将使用描述性分析在表格或图表中呈现。
背景：这项研究的结果将通过相关会议和同行评审的期刊进行传播。
■10.17605/OSF。IO/X2GYT。
方法：我们将对CPG进行系统的搜索。将使用“评估指南研究和评估-推荐卓越”工具分析接受大型肿瘤手术的个体的免疫调节底物营养补充建议。将使用评估准则研究和评估II工具对CPG进行分析。建议中引用的SR将使用评估系统审查的衡量工具II工具和有关审查异质性的其他问题进行分析。SRs和指南建议（适用时）中引用的临床试验将根据有关试验异质性的问题进行分析。结果将使用描述性分析在表格或图表中呈现。
背景：这项研究的结果将通过相关会议和同行评审的期刊进行传播。
■10.17605/OSF。IO/X2GYT。
