关键词: dedifferentiation differentiation epidermis epigenetic memory stem cell wound healing

Mesh : Animals Epidermal Cells / cytology metabolism Cell Differentiation / physiology Adult Stem Cells / physiology cytology Humans Epidermis / metabolism Mammals Epigenesis, Genetic Wound Healing / physiology Homeostasis

来  源:   DOI:10.1016/j.ydbio.2024.07.014

Abstract:
In this review we discuss how the mammalian interfollicular epidermis forms during development, maintains homeostasis, and is repaired following wounding. Recent studies have provided new insights into the relationship between the stem cell compartment and the differentiating cell layers; the ability of differentiated cells to dedifferentiate into stem cells; and the epigenetic memory of epidermal cells following wounding.
摘要:
在这篇综述中,我们讨论了哺乳动物毛囊间表皮在发育过程中如何形成,保持稳态,受伤后修复。最近的研究为干细胞区室与分化细胞层之间的关系提供了新的见解;分化细胞去分化为干细胞的能力;以及受伤后表皮细胞的表观遗传记忆。
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