Abstract：
Transposable elements (TEs) are essential components of eukaryotic genomes and subject to stringent regulatory mechanisms to avoid their potentially deleterious effects. However, numerous studies have verified the resurrection of TEs, particularly long interspersed nuclear element-1 (LINE-1), during preimplantation development, aging, cancer, and other age-related diseases. The LINE-1 family has also been implicated in several aging-related processes, including genomic instability, loss of heterochromatin, DNA methylation, and the senescence-associated secretory phenotype (SASP). Additionally, the role of the LINE-1 family in cancer development has also been substantiated. Research in this field has offered valuable insights into the functional mechanisms underlying LINE-1 activity, enhancing our understanding of aging regulation. This review provides a comprehensive summary of current findings on LINE-1 and their roles in aging and age-related diseases.
摘要：
转座因子(TE)是真核生物基因组的必要组分,并且受到严格的调节机制以避免其潜在的有害作用。然而,大量研究证实了TEs的复活，特别是长散布的核元素-1（LINE-1），在植入前发育过程中，老化，癌症,和其他与年龄有关的疾病。LINE-1家族也参与了几个与衰老相关的过程，包括基因组的不稳定性,异染色质的损失，DNA甲基化，和衰老相关分泌表型（SASP）。此外,LINE-1家族在癌症发展中的作用也得到了证实.该领域的研究为LINE-1活性的功能机制提供了有价值的见解，加强我们对衰老规律的理解。这篇综述全面总结了LINE-1的最新发现及其在衰老和年龄相关疾病中的作用。
