Abstract：
Objective: The effective treatment of central nervous system (CNS) disorders remains a significant challenge, primarily due to its molecular and structural complexity. Clinical translation of promising therapeutic agents is limited by the lack of optimal drug delivery systems capable of targeted, localized release of drugs to the brain and spinal cord.Approach: This review provides an overview of the potential of affinity-based drug delivery systems, which leverage molecular interactions to enhance the delivery and efficacy of therapeutic agents within the CNS.Main results: Various approaches, including hydrogels, micro- and nanoparticles, and functionalized biomaterials, are examined for their ability to provide local, sustained release of proteins, growth factors and other drugs.Significance: Furthermore, we present a detailed analysis of design considerations for developing effective affinity-based systems, incorporating insights from both existing literature and our group\'s research. These considerations include the biochemical modification of delivery vehicles and the optimization of physical and chemical properties to improve therapeutic outcomes.
摘要：
中枢神经系统（CNS）疾病的有效治疗仍然是一个重大挑战，主要是由于其分子和结构的复杂性。有前途的治疗剂的临床翻译是由于缺乏最佳的药物递送系统能够靶向，局部释放药物到大脑和脊髓。这篇综述概述了基于亲和力的药物递送系统的潜力，利用分子相互作用来增强CNS内治疗剂的递送和功效。各种方法，包括水凝胶，微米和纳米颗粒，和功能化的生物材料，检查它们提供本地服务的能力，蛋白质的持续释放，生长因子和其他药物。此外，我们详细分析了开发有效的基于亲和力的系统的设计考虑因素，结合了现有文献和我们小组研究的见解。这些考虑包括递送载体的生化改性和物理和化学性质的优化以改善治疗结果。
