PDF(Pubmed)
Abstract：
Primary lung cancer is rare in dogs and depending on the tumour stage and subtype, the prognosis can be poor. In this report, we describe a 10 year-old female intact Yorkshire terrier that presented progressive weight loss and chronic pain of unknown origin. Due to the poor condition of the dog, it was subsequently euthanized. Post-mortem evaluation revealed a single large mass in the left caudal lung lobe, with numerous pale, proliferative lesions of various sizes dispersed throughout all the lobes. Additionally, a solitary skin mass was palpated on the mid-thoracic body wall. Histopathological examination of the lung samples revealed multiple distinct, non-encapsulated, expansive neoplastic epithelial cell proliferations with dense cellularity, exhibiting growth patterns, ranging from papillary to micropapillary to solid, accompanied by central areas of necrosis. In some areas, microvilli-like structures were observed on the luminal cytoplasmic margins of the neoplastic cells. The histopathology of the skin mass closely resembled that of the lung. Electron microscopy of the skin samples revealed regions containing cells resembling the respiratory epithelium, along with cells exhibiting processes or microvilli indicative of cilia. The diagnosis was pulmonary adenocarcinoma with cutaneous metastasis. This is the first report of a canine with primary lung cancer that metastasized to the skin.
摘要：
原发性肺癌在狗中很少见，取决于肿瘤的分期和亚型，预后可能较差。在这份报告中,我们描述了一只10岁的雌性完整约克郡猎犬,它表现出进行性体重减轻和不明原因的慢性疼痛.由于狗的状况不佳，它随后被安乐死。验尸后评估显示左尾肺叶有一个大肿块，有许多苍白，各种大小的增生性病变分散在所有的叶。此外,在胸中体壁触诊了一个孤立的皮肤肿块。肺样本的组织病理学检查显示多个不同的，非封装，具有致密细胞性的扩张性肿瘤上皮细胞增殖，表现出增长模式，从乳头状到微乳头状到固体，伴有中央区域坏死。在某些地区,在肿瘤细胞的管腔细胞质边缘观察到微绒毛样结构。皮肤肿块的组织病理学与肺的组织病理学非常相似。皮肤样本的电子显微镜显示含有类似呼吸上皮的细胞的区域，以及表现出纤毛的过程或微绒毛的细胞。诊断为肺腺癌伴皮肤转移。这是第一次报告的犬原发性肺癌转移到皮肤。
