PDF(Pubmed)
Abstract：
Hepatitis E virus (HEV) poses significant health concerns worldwide, particularly among people living with HIV (PLWHIV), due to an increased risk of chronic infection and progression to cirrhosis in individuals with low CD4 cell counts. This study aimed to investigate the prevalence, chronicity potential, and risk factors of HEV infection among PLWHIV in Greece, where data are currently absent. A synchronic multicentric study encompassing five major Greek university hospitals was executed over 24 months, recruiting 696 PLWHIV participants. The prevalence of HEV IgG antibodies was 16.5%, with 8.6% showing evidence of acute HEV infection (HEV IgM). Active viral replication (HEV RNA) was present in 2.3% of the study population. Longitudinal analysis revealed that of the 25 initially anti-HEV IgM-positive individuals, only 3 seroconverted to IgG positivity, and among those with prior HEV RNA positivity (16), none showed evidence of active replication in subsequent tests. Comparative subgroup analysis highlighted the lack of significant differences in HIV-related parameters between HEV seropositive and seronegative individuals. Laboratory evaluations generally showed no significant disparities across most parameters; however, a higher seropositivity for Hepatitis A was observed in the HEV-positive subgroup. Our findings highlight a considerable prevalence of HEV among PLWHIV in Greece, with no observed cases of chronicity.
摘要：
戊型肝炎病毒（HEV）在全球范围内引起了重大的健康问题。特别是在艾滋病毒感染者(PLWHIV)中，由于在CD4细胞计数低的个体中慢性感染和进展为肝硬化的风险增加。本研究旨在调查患病率，慢性潜力，希腊PLWHIV中HEV感染的危险因素，数据目前不存在的地方。在24个月内执行了一项共时多中心研究，该研究涵盖了五个主要的希腊大学医院。招募696名PLWHIV参与者。HEVIgG抗体的患病率为16.5%,8.6%显示急性HEV感染(HEVIgM)的证据。活跃的病毒复制(HEVRNA)存在于2.3%的研究群体中。纵向分析显示，在25名最初抗HEVIgM阳性的个体中，只有3个血清转化为IgG阳性，在那些先前有HEVRNA阳性的人中(16)，在随后的测试中没有显示出活跃复制的证据。比较亚组分析强调了HEV血清阳性和血清阴性个体之间的HIV相关参数缺乏显着差异。实验室评估通常显示大多数参数之间没有显着差异；但是，在HEV阳性亚组中观察到较高的甲型肝炎血清阳性.我们的发现强调了希腊PLWHIV中HEV的相当普遍，没有观察到的慢性病例。
