PDF(Pubmed)
Abstract：
Self-healing hydrogels have good mechanical strength, can endure greater external force, and have the ability to heal independently, resulting in a strong bond between the wound and the material. Bacterial biofilm infections are life-threatening. Clindamycin (Cly) can be produced in the form of a self-healing hydrogel preparation. It is noteworthy that the antibacterial self-healing hydrogels show great promise as a wound dressing for bacterial biofilm infection. In this study, we developed a polyvinyl alcohol/borax (PVA/B) self-healing hydrogel wound dressing that releases Cly. Four ratios of PVA, B, and Cly were used to make self-healing hydrogels: F1 (4%:0.8%:1%), F2 (4%:1.2%:1%), F3 (1.6%:1%), and F4 (4%:1.6%:0). The results showed that F4 had the best physicochemical properties, including a self-healing duration of 11.81 ± 0.34 min, swelling ratio of 85.99 ± 0.12%, pH value of 7.63 ± 0.32, and drug loading of 98.34 ± 11.47%. The B-O-C cross-linking between PVA and borax caused self-healing, according to FTIR spectra. The F4 formula had a more equal pore structure in the SEM image. The PVA/B-Cly self-healing hydrogel remained stable at 6 ± 2 °C for 28 days throughout the stability test. The Korsmeyer-Peppas model released Cly by Fickian diffusion. In biofilm-infected mouse wounds, PVA/B-Cly enhanced wound healing and re-epithelialization. Our results indicate that the PVA/B-Cly produced in this work has reliable physicochemical properties for biofilm-infected wound therapy.
摘要：
自修复水凝胶具有良好的机械强度，可以承受更大的外力，并且有独立治愈的能力，导致伤口和材料之间的牢固结合。细菌生物膜感染危及生命。克林霉素(Cly)可以以自修复水凝胶制剂的形式生产。值得注意的是,抗菌自修复水凝胶显示出作为细菌生物膜感染的伤口敷料的巨大前景。在这项研究中,我们开发了一种可释放Cly的聚乙烯醇/硼砂(PVA/B)自愈水凝胶伤口敷料。四种比例的PVA，B,和Cly用于制造自修复水凝胶：F1（4％：0.8％：1％），F2（4%：1.2%：1%），F3（1.6%：1%），和F4（4%：1.6%：0）。结果表明,F4具有最佳的理化性质,包括11.81±0.34分钟的自我修复持续时间，溶胀率85.99±0.12%，pH值为7.63±0.32,载药量为98.34±11.47%。PVA和硼砂之间的B-O-C交联导致自愈，根据FTIR光谱。F4配方在SEM图像中具有更相等的孔结构。在整个稳定性测试中,PVA/B-Cly自修复水凝胶在6±2°C下保持稳定28天。Korsmeyer-Peppas模型通过Fickian扩散释放了Cly。在生物膜感染的小鼠伤口中，PVA/B-Cly增强伤口愈合和上皮再形成。我们的结果表明，在这项工作中产生的PVA/B-Cly具有可靠的物理化学性质，可用于生物膜感染的伤口治疗。
