PDF(Pubmed)
Abstract：
The study aimed to perform a comprehensive in vitro and in vivo evaluation of a newly developed, patent-pending, powder-to-hydrogel, film-forming polymer complex base, which possesses tissue-protective and microbiome-supportive properties, and to compare its characteristics with poloxamer 407. The study used a combination of in vitro assays, including tissue viability and cell migration, and in vivo wound healing evaluations in male diabetic mice. Microbiome dynamics at wound sites were also analyzed. The in vitro assays demonstrated that the polymer complex base was non-cytotoxic and that it enhanced cell migration over poloxamer 407. In vivo, the polymer complex base demonstrated superior wound healing capabilities, particularly in combination with misoprostol and phenytoin, as evidenced by the reduced wound area and inflammation scores. Microbiome analysis revealed favorable shifts in bacterial populations associated with the polymer complex base-treated wounds. The polymer complex base demonstrates clinical significance in wound care, potentially offering improved healing, safety and microbiome support. Its transformative properties and efficacy in drug delivery make it a promising candidate for advanced wound care applications, particularly in chronic wound management.
摘要：
该研究旨在对新开发的药物进行全面的体外和体内评估，正在申请专利，粉末到水凝胶，成膜聚合物复合基质，具有组织保护和微生物组支持特性，并将其与泊洛沙姆407的特性进行比较。这项研究使用了体外试验的组合，包括组织活力和细胞迁移，和雄性糖尿病小鼠体内伤口愈合评估。还分析了伤口部位的微生物组动力学。体外测定证明,聚合物复合物碱基是非细胞毒性的,并且其相对于泊洛沙姆407增强细胞迁移。在体内,聚合物复合基质表现出优异的伤口愈合能力，特别是与米索前列醇和苯妥英合用，如减少的伤口面积和炎症评分所证明的。微生物组分析显示，与聚合物复合物碱处理的伤口相关的细菌种群发生了有利的变化。聚合物复合基质在伤口护理中显示出临床意义，可能提供更好的治疗，安全和微生物组支持。其在药物递送中的转化特性和功效使其成为高级伤口护理应用的有希望的候选者，特别是在慢性伤口管理中。
