PDF(Pubmed)
Abstract：
As the leading cause of fungal skin infections around the globe, dermatophytes are responsible for a multitude of skin ailments, ranging from athlete\'s foot to ringworm. Due to the combination of its growing prevalence and antifungal misuse, antifungal-resistant dermatophyte strains like Trichophyton indotineae have begun to emerge, posing a significant global health risk. The emergence of these resistant dermatophytes highlights a critical need to identify alternative methods of treating dermatophyte infections. In our study, we utilized a 405 nm LED to establish that blue light can effectively inactivate catalase within a variety of both susceptible and resistant dermatophytes. Through this catalase inactivation process, light-treated dermatophytes were found to exhibit increased sensitivity to reactive oxygen species (ROS)-producing agents, improving the performance of antimicrobial agents such as H2O2 and amphotericin B. Our findings further demonstrate that light-induced catalase inactivation can inhibit the formation and polarized growth of hyphae from dermatophytes, suppressing biomass formation. Thus, by increasing ROS sensitization and inhibiting hyphal development, catalase-deactivating blue light offers a potential non-invasive and non-drug-reliant method of managing dermatophyte infections, opening new avenues for the potential treatment of these common infections in conjunction with existing treatments.
摘要：
作为全球真菌皮肤感染的主要原因，皮肤癣菌导致多种皮肤疾病，从运动员的脚到癣。由于其日益流行和抗真菌滥用的结合，抗真菌的皮肤癣菌菌株如吲哚毛癣菌已经开始出现，构成重大的全球健康风险。这些抗性皮肤癣菌的出现突出了确定治疗皮肤癣菌感染的替代方法的关键需求。在我们的研究中,我们使用405nmLED来确定蓝光可以有效地灭活各种敏感和抗性皮肤癣菌中的过氧化氢酶。通过过氧化氢酶失活过程,发现光处理的皮肤癣菌对活性氧（ROS）产生剂的敏感性增加，我们的研究结果进一步表明，光诱导过氧化氢酶失活可以抑制皮肤癣菌菌丝的形成和极化生长，抑制生物量的形成。因此，通过增加ROS敏化和抑制菌丝发育，过氧化氢酶灭活蓝光提供了一种潜在的非侵入性和非药物依赖的方法来管理皮肤癣菌感染，与现有治疗相结合，为这些常见感染的潜在治疗开辟了新的途径。
