PDF(Pubmed)
Abstract：
We present a case of a man immunocompromised due to myelodysplastic syndrome with Candida krusei fungemia who had a rising cell-free DNA (cfDNA) giant magnetoresistance (GMR) signal when tested daily using plasma blood samples. With the rise in GMR signal paralleling the development of skin lesions in this patient, we conclude that cfDNA can be used to indicate uncontrolled infection and thus help monitor response to therapy. This index patient provides evidence that an invasive fungal infection requires both direct antifungal therapy and an intact immune system to control the infection. This biosensing platform has been simplified to potentially serve as a point-of-care test, setting it apart by overcoming the three common barriers of cfDNA testing: complexity, cost, and time.
摘要：
我们介绍了一例因骨髓增生异常综合征而导致免疫受损的男子，该男子患有克鲁斯假丝酵母真菌血症，每天使用血浆血液样本进行测试时，其无细胞DNA（cfDNA）巨磁阻（GMR）信号升高。随着GMR信号的上升，该患者皮肤病变的发展，我们得出的结论是，cfDNA可用于指示不受控制的感染，从而有助于监测对治疗的反应。该指标患者提供了侵袭性真菌感染需要直接抗真菌治疗和完整的免疫系统来控制感染的证据。这个生物传感平台已经被简化，有可能作为一个即时测试，通过克服cfDNA测试的三个常见障碍：复杂性，成本,和时间。
