PDF(Pubmed)
Abstract：
The IgLON family of cell adhesion molecules consists of five members (LSAMP, OPCML, neurotrimin, NEGR1, and IgLON5) discovered as supporters of neuronal development, axon growth and guidance, and synapse formation and maintenance. Tumour suppression properties have recently been emerging based on antiproliferative effects through the modulation of oncogenic pathways. Available evidence endorses a role for non-coding RNAs or microRNAs as relevant controllers of IgLON molecule expression that can impact their critical physiological and pathological roles. Current findings support a function for long non-coding RNAs and microRNAs in the modulation of LSAMP expression in cell senescence, cancer biogenesis, addiction, and pulmonary hypertension. For OPCML, data point to a role for several microRNAs in the control of tumorigenesis. MicroRNAs were detected in neurotrimin-mediated functions in cancer biogenesis and in Schwann cell responses to peripheral nerve injury. For NEGR1, studies have mainly investigated microRNA involvement in neuronal responses to ischaemic injury, although data also exist about tumorigenesis and endothelial cell dysfunction. For IgLON5, information is only available about microRNA involved in myocardial infarction. In conclusion, despite much information being still missing and further research needed, the emerging picture favours a model in which non-coding RNAs exert a crucial role in modulating IgLON expression, ultimately affecting their important physiological functions.
摘要：
细胞粘附分子的IgLON家族由五个成员组成(LSAMP，OPCML,神经蛋白,NEGR1和IgLON5）被发现是神经元发育的支持者，轴突生长和指导，突触的形成和维持。最近已经出现了基于通过调节致癌途径的抗增殖作用的肿瘤抑制特性。现有证据支持非编码RNA或microRNA作为IgLON分子表达的相关控制器的作用，可以影响其关键的生理和病理作用。目前的发现支持长链非编码RNA和microRNA在调节细胞衰老中LSAMP表达中的功能，癌症生物发生，上瘾,和肺动脉高压。对于OPCML，数据表明几种microRNA在控制肿瘤发生中的作用。在神经蛋白介导的癌症生物发生和雪旺氏细胞对周围神经损伤的反应中检测到微小RNA。对于NEGR1，研究主要研究了microRNA参与神经元对缺血性损伤的反应，尽管也有关于肿瘤发生和内皮细胞功能障碍的数据。对于IgLON5，仅可获得有关与心肌梗死有关的microRNA的信息。总之,尽管仍然缺少很多信息，需要进一步的研究，新出现的图片支持一个模型，其中非编码RNA在调节IgLON表达中发挥关键作用，最终影响其重要的生理功能。
