PDF(Pubmed)
Abstract：
S. salivarius M18 administration has been proven to provide positive effects on periodontal health; however, there is still no consensus on the optimum duration of probiotic administration. This study aimed to evaluate the effect of three months of probiotic supplementation on bleeding on probing, signs of gingival inflammation, and dental biofilm. Sixty-two eligible individuals with gingivitis were enrolled in this placebo-controlled, double-blind trial and randomly allocated to the M18 or control groups. Primary outcomes were changes in gingival condition (gingival index, GI; gingival bleeding index, GBI) after 1, 2, and 3 months of lozenges administration and after a one-month washout. Secondary outcomes included changes in the Quigley-Hein plaque index (modified by Turesky et al.) after 1, 2, and 3 months of lozenges administration and after a washout. In total, 60 individuals completed the study (31 and 29 in the M18 group and the control group, respectively). No severe adverse events were reported. Probiotic supplementation resulted in a significant decrease in gingival bleeding at 1 month (effect size 1.09 [CI95%: 0.55-1.63]), 2 months (effect size 0.78 [CI95%: 0.26-1.30]), and 3 months (effect size 0.67 [CI95%: 0.15-1.18]) and a significant reduction in dental plaque accumulation at 2 months (effect size 0.63 [CI95%: 0.12-1.14]) and 3 months (effect size 0.55 [CI95%: 0.03-1.05]). A three-month supplementation with the probiotic resulted in a significant reduction in gingival bleeding and biofilm accumulation; however, a long-lasting effect is not expected, indicating the need for probiotic intake on a long-term basis.
摘要：
美国唾液M18给药已被证明对牙周健康提供积极的影响;然而，对于益生菌的最佳给药时间仍未达成共识.这项研究旨在评估三个月的益生菌补充剂对探查出血的影响，牙龈发炎的迹象，和牙科生物膜。62名符合条件的牙龈炎患者参加了这项安慰剂对照，双盲试验，随机分配到M18或对照组。主要结果是牙龈状况的变化(牙龈指数，胃肠道;牙龈出血指数,GBI）在1、2和3个月的锭剂施用后以及一个月的洗脱后。次要结局包括Quigley-Hein菌斑指数的变化(由Turesky等人修改。)在服用锭剂1、2和3个月后和冲洗后。总的来说,60人完成了研究（M18组和对照组分别为31和29人，分别)。未报告严重不良事件。益生菌补充剂导致1个月时牙龈出血显著减少（效应大小1.09[CI95%：0.55-1.63]），2个月(效应大小0.78[CI95%：0.26-1.30])，和3个月（效应大小0.67[CI95%：0.15-1.18]）和2个月（效应大小0.63[CI95%：0.12-1.14]）和3个月（效应大小0.55[CI95%：0.03-1.05]）时牙菌斑积聚显着减少。三个月补充益生菌可显著减少牙龈出血和生物膜积累；然而，不会有持久的效果，表明长期摄入益生菌的需要。
