PDF(Pubmed)
Abstract：
Aerogels are lightweight and highly porous materials that have been found to have great potential in biomedical research because of some of their unique properties, such as their high surface area, tunable porosity, and biocompatibility. Researchers have been exploring ways to use aerogels to create biomimetic scaffolds inspired by natural extracellular matrices (ECMs) for various biomedical applications. Aerogel scaffolds can serve as three-dimensional (3D) templates for cell growth and tissue regeneration, promoting wound healing and tissue repair. Additionally, aerogel-based scaffolds have great potential in controlled drug delivery systems, where their high surface area and porosity enable the efficient loading and release of therapeutic agents. In this review, we discuss biopolymer-based biomimetic aerogel scaffolds for tissue engineering, drug delivery, and biosensors. Finally, we also discuss the potential directions in the development of aerogel-based biomimetic scaffolds.
摘要：
气凝胶是一种轻质且高度多孔的材料，由于其一些独特的性能，在生物医学研究中具有巨大的潜力，比如它们的高表面积，可调孔隙率，和生物相容性。研究人员一直在探索使用气凝胶来创建仿生支架的方法，该支架受天然细胞外基质（ECM）的启发，用于各种生物医学应用。气凝胶支架可以作为细胞生长和组织再生的三维（3D）模板，促进伤口愈合和组织修复。此外,气凝胶支架在控制药物递送系统中具有巨大的潜力，其中它们的高表面积和孔隙率使得治疗剂的有效负载和释放成为可能。在这次审查中,我们讨论了用于组织工程的基于生物聚合物的仿生气凝胶支架，药物输送,和生物传感器。最后,我们还讨论了气凝胶基仿生支架的潜在发展方向。
