Abstract：
OBJECTIVE: Compare the effectiveness of palatoplasty and pharyngoplasty procedures at resolving hypernasality in patients with 22q11.2 deletion syndrome (22q).
METHODS: Retrospective cohort study.
METHODS: Metropolitan children\'s hospital.
METHODS: Fourteen patients with 22q presenting for management of velopharyngeal insufficiency.
METHODS: Palatoplasty or pharyngoplasty procedure.
METHODS: Resolution of hypernasality 12 months postoperatively.
RESULTS: Both procedure groups had a mean preoperative velopharyngeal gap of 6.2 mm during phonation. No patient who underwent palatoplasty achieved resolution of hypernasality; 1/7 patients had worse hypernasality, 4/7 had no change, and 2/7 had improved hypernasality. In contrast, hypernasality was resolved in 6/7 patients in the pharyngoplasty group, which was significantly (P = .03) higher than the palatoplasty group.
CONCLUSIONS: In patients with 22q, palatoplasty procedures may be less effective than pharyngoplasty procedures at resolving hypernasality. This may be due to underlying anatomic or physiologic differences, such as increased pharyngeal depth and hypodynamic muscles.
METHODS: Retrospective cohort study.
METHODS: Metropolitan children\'s hospital.
METHODS: Fourteen patients with 22q presenting for management of velopharyngeal insufficiency.
METHODS: Palatoplasty or pharyngoplasty procedure.
METHODS: Resolution of hypernasality 12 months postoperatively.
RESULTS: Both procedure groups had a mean preoperative velopharyngeal gap of 6.2 mm during phonation. No patient who underwent palatoplasty achieved resolution of hypernasality; 1/7 patients had worse hypernasality, 4/7 had no change, and 2/7 had improved hypernasality. In contrast, hypernasality was resolved in 6/7 patients in the pharyngoplasty group, which was significantly (P = .03) higher than the palatoplasty group.
CONCLUSIONS: In patients with 22q, palatoplasty procedures may be less effective than pharyngoplasty procedures at resolving hypernasality. This may be due to underlying anatomic or physiologic differences, such as increased pharyngeal depth and hypodynamic muscles.
摘要：
目的：比较22q11.2缺失综合征（22q）患者的腭成形术和咽部成形术在解决高鼻音方面的有效性。
方法：回顾性队列研究。
方法：大都会儿童医院。
方法：14例22q患者就诊于咽喉功能不全。
方法：腭成形术或咽部成形术。
方法：术后12个月解决鼻出血。
结果：两组术前发音时的平均咽喉间隙为6.2mm。没有患者行pal口移植术后鼻塞消退；1/7的患者鼻塞加重，4/7没有变化，2/7改善了鼻塞。相比之下,咽部成形术组6/7的患者鼻塞增多,显著（P=0.03）高于腭成形术组。
结论：在22q患者中，在解决鼻高的问题上，腭成形术的效果可能不如咽成形术。这可能是由于潜在的解剖或生理差异，如咽部深度增加和肌肉动力不足。
方法：回顾性队列研究。
方法：大都会儿童医院。
方法：14例22q患者就诊于咽喉功能不全。
方法：腭成形术或咽部成形术。
方法：术后12个月解决鼻出血。
结果：两组术前发音时的平均咽喉间隙为6.2mm。没有患者行pal口移植术后鼻塞消退；1/7的患者鼻塞加重，4/7没有变化，2/7改善了鼻塞。相比之下,咽部成形术组6/7的患者鼻塞增多,显著（P=0.03）高于腭成形术组。
结论：在22q患者中，在解决鼻高的问题上，腭成形术的效果可能不如咽成形术。这可能是由于潜在的解剖或生理差异，如咽部深度增加和肌肉动力不足。
