Abstract：
OBJECTIVE: Ocular ischemic syndrome can be the first and only hint of life-threatening carotid artery disease. The early recognition of carotid stenosis-related retinal signs, as well as the comprehension of the pathophysiology behind retinal changes could become relevant for physicians to predict the risk of stroke. The aim of this study is to assess the carotid artery disease-induced early structural retinochoroidal changes by means of swept-source optical coherence tomography (SS-OCT).
METHODS: A prospective observational study was conducted in 72 eyes with carotid stenosis. According to the degree of stenosis, the participants were divided into a normal group (34 eyes), a mild-moderate stenosis group (22 eyes), a severe stenosis group (16 eyes). SS-OCT and OCTA were performed to scan macular fovea. Central macular thickness (CMT), subfoveal choroidal thickness (SCT) and foveal avascular zona (FAZ) area were the major measurements for our study.
RESULTS: CMT was significantly thicker in group 3 when compared to group 2 and 1. SCT was significantly thinner in group 3 vs group 1, being thicker in group 2 when compared to group 1. No significant differences were obtained when comparing FAZ in the superficial and middle capillary plexus although it was significant when comparing the FAZ in the deep capillary plexus between group 1 and 3.
CONCLUSIONS: internal carotid artery stenosis greater than 70% leads to a significant increase in CMT and a decrease in SCT prior the development of clinical findings of ocular ischemia syndrome.
METHODS: A prospective observational study was conducted in 72 eyes with carotid stenosis. According to the degree of stenosis, the participants were divided into a normal group (34 eyes), a mild-moderate stenosis group (22 eyes), a severe stenosis group (16 eyes). SS-OCT and OCTA were performed to scan macular fovea. Central macular thickness (CMT), subfoveal choroidal thickness (SCT) and foveal avascular zona (FAZ) area were the major measurements for our study.
RESULTS: CMT was significantly thicker in group 3 when compared to group 2 and 1. SCT was significantly thinner in group 3 vs group 1, being thicker in group 2 when compared to group 1. No significant differences were obtained when comparing FAZ in the superficial and middle capillary plexus although it was significant when comparing the FAZ in the deep capillary plexus between group 1 and 3.
CONCLUSIONS: internal carotid artery stenosis greater than 70% leads to a significant increase in CMT and a decrease in SCT prior the development of clinical findings of ocular ischemia syndrome.
摘要：
目的：眼部缺血综合征可能是危及生命的颈动脉疾病的第一个也是唯一的提示。颈动脉狭窄相关视网膜征象的早期识别,以及对视网膜变化背后的病理生理学的理解可能成为医生预测中风风险的相关因素。这项研究的目的是通过扫频源光学相干断层扫描（SS-OCT）评估颈动脉疾病引起的早期结构性视网膜脉络膜变化。
方法：在72眼颈动脉狭窄患者中进行了一项前瞻性观察研究。根据狭窄程度,参与者被分为正常组(34只眼)，轻度-中度狭窄组（22眼），严重狭窄组（16眼）。进行SS-OCT和OCTA扫描黄斑中央凹。中央黄斑厚度(CMT),中心凹下脉络膜厚度（SCT）和中心凹无血管带（FAZ）面积是我们研究的主要指标。
结果：与第2组和第1组相比，第3组的CMT明显更厚。与第1组相比，第3组的SCT明显变薄，第2组的SCT增厚。在比较浅层和中层毛细血管丛的FAZ时，没有显着差异，尽管在比较第1组和第3组之间的深层毛细血管丛的FAZ时显着。
结论：颈内动脉狭窄大于70%导致CMT显著增加，而在出现眼缺血综合征的临床表现之前，SCT显著减少。
方法：在72眼颈动脉狭窄患者中进行了一项前瞻性观察研究。根据狭窄程度,参与者被分为正常组(34只眼)，轻度-中度狭窄组（22眼），严重狭窄组（16眼）。进行SS-OCT和OCTA扫描黄斑中央凹。中央黄斑厚度(CMT),中心凹下脉络膜厚度（SCT）和中心凹无血管带（FAZ）面积是我们研究的主要指标。
结果：与第2组和第1组相比，第3组的CMT明显更厚。与第1组相比，第3组的SCT明显变薄，第2组的SCT增厚。在比较浅层和中层毛细血管丛的FAZ时，没有显着差异，尽管在比较第1组和第3组之间的深层毛细血管丛的FAZ时显着。
结论：颈内动脉狭窄大于70%导致CMT显著增加，而在出现眼缺血综合征的临床表现之前，SCT显著减少。
