Abstract：
OBJECTIVE: This study aims to investigate the association between blood estradiol level and two different etiologies of corneal ectasia in premenopausal women.
METHODS: This is an observational case-control study with three groups of women. Group 1 included women with keratoconus. Group 2 included women with post refractive surgery ectasia (PRSE). Group 3 was the control group. Venous blood for the measurement of estradiol was collected in order to assess the relationship between estradiol levels and ectasia. Participant\'s age, regular cycle (yes/no) and oral contraceptive pills (OCP) use (yes/no) was also documented. We compared the differences in estradiol levels between the 3 groups. Logistic regression was used to detect variables\' effect on participants\' chance to ectasia.
RESULTS: Ninety-six women were enrolled: 36 (37%), 29 (30%), and 31 (32%) in the keratoconus, PRSE, and control group, respectively. The mean age of the participants was 29.8 ± 3.2, 31.9 ± 2.6, and 30.7 ± 3.5 years, respectively (p = 0.04, between groups 1 and 2). Estradiol levels [pg/mL] were 38.0 ± 2.4, 43.4 ± 2.4, and 28.6 ± 3.9, respectively (p < 0.001, between any pair of groups). Two multivariate logistic regression models adjusted to age, regular cycle, and OCP use, indicated that higher blood estradiol levels were associated with an increased risk of ectasia (OR = 2.71 and 2.44, respectively; p < 0.001).
CONCLUSIONS: Corneal ectasia may be associated with elevated blood estradiol levels. Estradiol measurements could be useful in women with keratoconus or in women who undergo refractive surgery.
METHODS: This is an observational case-control study with three groups of women. Group 1 included women with keratoconus. Group 2 included women with post refractive surgery ectasia (PRSE). Group 3 was the control group. Venous blood for the measurement of estradiol was collected in order to assess the relationship between estradiol levels and ectasia. Participant\'s age, regular cycle (yes/no) and oral contraceptive pills (OCP) use (yes/no) was also documented. We compared the differences in estradiol levels between the 3 groups. Logistic regression was used to detect variables\' effect on participants\' chance to ectasia.
RESULTS: Ninety-six women were enrolled: 36 (37%), 29 (30%), and 31 (32%) in the keratoconus, PRSE, and control group, respectively. The mean age of the participants was 29.8 ± 3.2, 31.9 ± 2.6, and 30.7 ± 3.5 years, respectively (p = 0.04, between groups 1 and 2). Estradiol levels [pg/mL] were 38.0 ± 2.4, 43.4 ± 2.4, and 28.6 ± 3.9, respectively (p < 0.001, between any pair of groups). Two multivariate logistic regression models adjusted to age, regular cycle, and OCP use, indicated that higher blood estradiol levels were associated with an increased risk of ectasia (OR = 2.71 and 2.44, respectively; p < 0.001).
CONCLUSIONS: Corneal ectasia may be associated with elevated blood estradiol levels. Estradiol measurements could be useful in women with keratoconus or in women who undergo refractive surgery.
摘要：
目的：本研究旨在探讨绝经前妇女血雌二醇水平与两种不同病因角膜扩张之间的关系。
方法：这是一项观察性病例对照研究，包括三组女性。第1组包括患有圆锥角膜的女性。第2组包括屈光手术后扩张（PRSE）的女性。第3组为对照组。收集用于测量雌二醇的静脉血以评估雌二醇水平与扩张之间的关系。参与者的年龄，还记录了常规周期（是/否）和口服避孕药（OCP）的使用（是/否）。我们比较了3组之间雌二醇水平的差异。Logistic回归用于检测变量对参与者扩张机会的影响。
结果：共纳入96名女性：36名（37%），29（30%），圆锥角膜31（32%），PRSE,和对照组，分别。参与者的平均年龄为29.8±3.2、31.9±2.6和30.7±3.5岁，分别(第1组和第2组之间p=0.04)。雌二醇水平[pg/mL]分别为38.0±2.4、43.4±2.4和28.6±3.9(任何一对组间p<0.001)。两个多变量逻辑回归模型调整为年龄，定期循环,和OCP使用，表明较高的血雌二醇水平与扩张风险增加相关(OR分别=2.71和2.44;p<0.001).
结论：角膜扩张症可能与血雌二醇水平升高有关。雌二醇测量可能对圆锥角膜女性或接受屈光手术的女性有用。
方法：这是一项观察性病例对照研究，包括三组女性。第1组包括患有圆锥角膜的女性。第2组包括屈光手术后扩张（PRSE）的女性。第3组为对照组。收集用于测量雌二醇的静脉血以评估雌二醇水平与扩张之间的关系。参与者的年龄，还记录了常规周期（是/否）和口服避孕药（OCP）的使用（是/否）。我们比较了3组之间雌二醇水平的差异。Logistic回归用于检测变量对参与者扩张机会的影响。
结果：共纳入96名女性：36名（37%），29（30%），圆锥角膜31（32%），PRSE,和对照组，分别。参与者的平均年龄为29.8±3.2、31.9±2.6和30.7±3.5岁，分别(第1组和第2组之间p=0.04)。雌二醇水平[pg/mL]分别为38.0±2.4、43.4±2.4和28.6±3.9(任何一对组间p<0.001)。两个多变量逻辑回归模型调整为年龄，定期循环,和OCP使用，表明较高的血雌二醇水平与扩张风险增加相关(OR分别=2.71和2.44;p<0.001).
结论：角膜扩张症可能与血雌二醇水平升高有关。雌二醇测量可能对圆锥角膜女性或接受屈光手术的女性有用。
