UNASSIGNED: We evaluated the data of meningioma patients who were seen in our tertiary center over 10 years-8.5 years retrospectively and 1.5 years prospectively. Their archival hematoxylin and eosin stained slides were reviewed and re-graded according to the World Health Organization 2021 criteria. Immunohistochemical analysis for ER, PR, and Ki-67 was performed on all grade 2 and grade 3 meningiomas and 30 cases of grade 1 formalin-fixed, paraffin-embedded samples.
UNASSIGNED: Of the 276 cases included in the study, there were 231 (83.7%) cases of grade 1 meningioma, 34 (12.3%) cases of grade 2, and 11 (4.0%) cases of grade 3. ER was positive in 26.0% of grade 1 tumors, 5.8% of grade 2, and 0.0% of grade 3. PR was positive in 70.0% of grade 1 tumors, 20.0% of grade 2, and 18.0% of grade 3. The Ki-67/MIB-1 labeling index (LI) was 2.1 in grade 1, 6.3 in grade 2, and 13.4 in grade 3 tumors. For both PR and Ki-67, the differences between grades 1, 2, and 3 tumors were significant (p < 0.001). There was a significant inverse relationship between mean Ki-67 LI and PR status, with increasing grade of tumor.
UNASSIGNED: Ki-67/MIB-1 LI has significant positive correlations with meningioma grade and its recurrence, which makes it a useful auxiliary method for the routine assessment of meningiomas, especially in patients with borderline atypia. The expression of PR, on the other hand, is a positive prognostic indicator and has a substantial correlation with histological grade. In cases of subtotal resection, high proliferative/recurrence rates, and borderline histopathology, the PR status in combination with the MIB-1 LI can offer insights into the behavior and the recurrence probability of a meningioma.
■我们评估了在我们的三级中心观察的脑膜瘤患者的数据,这些患者在10年-8.5年和1.5年的时间进行了回顾性分析。根据世界卫生组织2021年的标准,对其存档的苏木精和曙红染色的载玻片进行了审查和重新分级。ER的免疫组织化学分析,PR,对所有2级和3级脑膜瘤和30例福尔马林固定的1级脑膜瘤进行Ki-67,石蜡包埋的样品。
■在纳入研究的276例病例中,1级脑膜瘤231例(83.7%),2级34例(12.3%),3级11例(4.0%)。ER在26.0%的1级肿瘤中呈阳性,2级的5.8%,3级的0.0%。70.0%的1级肿瘤PR阳性,2级的20.0%,3级的18.0%。Ki-67/MIB-1标记指数(LI)在1级肿瘤中为2.1,在2级肿瘤中为6.3,在3级肿瘤中为13.4。对于PR和Ki-67,1级、2级和3级肿瘤之间的差异是显著的(p<0.001)。平均Ki-67LI和PR状态之间存在显著的反比关系,随着肿瘤分级的增加。
■Ki-67/MIB-1LI与脑膜瘤分级及其复发呈显著正相关,这使得它成为脑膜瘤常规评估的有用辅助方法,尤其是有临界异型的患者。PR的表达,另一方面,是一个积极的预后指标,并与组织学分级有实质性的相关性。在次全切除的情况下,高增殖/复发率,和临界组织病理学,PR状态结合MIB-1LI可以提供对脑膜瘤行为和复发概率的见解。