PDF(Pubmed)
Abstract：
UNASSIGNED: Optic neuritis is an inflammatory disorder of the optic nerve and is often the initial manifestation of systemic demyelinating diseases such as multiple sclerosis (MS), neuromyelitis optic spectrum disorder (NMOSD), and myelin-oligodendrocyte glycoprotein (MOG) antibody-mediated disease. There are ethnic variations in the etiology of optic neuritis across the world. While multiple sclerosis is common in the West, NMOSD and MOG are more common causes in Asian patients. There is a paucity of reports on the clinical profile of optic neuritis in the Middle East.
UNASSIGNED: To study the demographic and clinical features of patients with new onset optic neuritis in a main tertiary care center.
UNASSIGNED: A retrospective study of cases with new-onset optic neuritis at a tertiary care center between 2012 and 2022. The clinical and demographic characteristics were obtained from medical records and were summarized using descriptive statistics. Univariate analysis and multivariate analysis to assess the short-term visual outcome.
UNASSIGNED: Seventy-one patients with new-onset optic neuritis (70 unilateral and one bilateral) were included in the study. The mean age was 33.3 years, they were predominantly females (73 %), and most of the cases were MS (53 %) followed by idiopathic optic neuritis (42.3 %). Final visual acuity of at least 20/40 was seen in at least 91.5 %.
UNASSIGNED: While the clinical profile of patients in this study closely resembles the Optic Neuritis Treatment Trial with a high incidence of MS and a good visual outcome in most patients and a good response to intravenous steroids, there is a significant proportion of idiopathic optic neuritis cases that may need to be better characterized with longer follow up and repeated serum biomarker testing.
UNASSIGNED: To study the demographic and clinical features of patients with new onset optic neuritis in a main tertiary care center.
UNASSIGNED: A retrospective study of cases with new-onset optic neuritis at a tertiary care center between 2012 and 2022. The clinical and demographic characteristics were obtained from medical records and were summarized using descriptive statistics. Univariate analysis and multivariate analysis to assess the short-term visual outcome.
UNASSIGNED: Seventy-one patients with new-onset optic neuritis (70 unilateral and one bilateral) were included in the study. The mean age was 33.3 years, they were predominantly females (73 %), and most of the cases were MS (53 %) followed by idiopathic optic neuritis (42.3 %). Final visual acuity of at least 20/40 was seen in at least 91.5 %.
UNASSIGNED: While the clinical profile of patients in this study closely resembles the Optic Neuritis Treatment Trial with a high incidence of MS and a good visual outcome in most patients and a good response to intravenous steroids, there is a significant proportion of idiopathic optic neuritis cases that may need to be better characterized with longer follow up and repeated serum biomarker testing.
摘要：
■视神经炎是视神经的炎症性疾病，通常是系统性脱髓鞘疾病如多发性硬化症（MS）的最初表现，神经脊髓炎视谱障碍（NMOSD），和髓磷脂-少突胶质细胞糖蛋白（MOG）抗体介导的疾病。世界各地视神经炎的病因存在种族差异。虽然多发性硬化症在西方很常见，NMOSD和MOG是亚洲患者中更常见的原因。关于中东视神经炎的临床特征的报道很少。
■在主要的三级护理中心研究新发神经炎患者的人口统计学和临床特征。
■2012年至2022年在三级护理中心进行的新发病视神经炎病例的回顾性研究。从病历中获得临床和人口统计学特征，并使用描述性统计进行总结。单变量分析和多变量分析评估短期视觉结果。
■71例新发的视神经炎患者（70例单侧和1例双侧）被纳入研究。平均年龄为33.3岁,她们主要是女性(73%)，大多数病例是MS（53％），其次是特发性视神经炎（42.3％）。在至少91.5%中看到至少20/40的最终视敏度。
虽然本研究中患者的临床特征与视神经炎治疗试验非常相似，但大多数患者的MS发病率高，视力结果良好，对静脉注射类固醇有良好的反应，有相当比例的特发性视神经炎病例可能需要通过更长时间的随访和重复的血清生物标志物检测来更好地表征.
■在主要的三级护理中心研究新发神经炎患者的人口统计学和临床特征。
■2012年至2022年在三级护理中心进行的新发病视神经炎病例的回顾性研究。从病历中获得临床和人口统计学特征，并使用描述性统计进行总结。单变量分析和多变量分析评估短期视觉结果。
■71例新发的视神经炎患者（70例单侧和1例双侧）被纳入研究。平均年龄为33.3岁,她们主要是女性(73%)，大多数病例是MS（53％），其次是特发性视神经炎（42.3％）。在至少91.5%中看到至少20/40的最终视敏度。
虽然本研究中患者的临床特征与视神经炎治疗试验非常相似，但大多数患者的MS发病率高，视力结果良好，对静脉注射类固醇有良好的反应，有相当比例的特发性视神经炎病例可能需要通过更长时间的随访和重复的血清生物标志物检测来更好地表征.
