UNASSIGNED: Adults admitted to five Mayo Clinic hospitals with COVID-19 between 03/2020-01/2022 were evaluated. PTX/PM was defined by imaging. Descriptive analyses and a matched (age, sex, admission month, COVID-19 severity) cohort comparison was performed. Hospital mortality, length of stay (LOS), and predisposing factors were assessed.
UNASSIGNED: Among 6663 patients, 197 had PTX/PM (3 %) (75 PM, 40 PTX, 82 both). The median age was 59, with 71 % males. Exposure to invasive and non-invasive mechanical ventilation and high-flow nasal cannula before PTX/PM were 42 %, 17 %, and 20 %, respectively. Among isolated PTX and PM/PTX patients 70 % and 53.7 % underwent an intervention, respectively, while 96 % of the PM-only group was followed conservatively.A total of 171 patients with PTX/PM were compared to 171 matched controls. PTX/PM patients had more underlying lung disease (40.9 vs. 23.4 %, p < 0.001) and lower median body mass index (BMI) (29.5 vs. 31.3 kg/m2, p = .007) than controls. Among patients with available data, PTX/PM patients had higher median positive end-expiratory and plateau pressures than controls; however, differences were not significant (10 vs. 8 cmH2O; p = 0.38 and 28 vs. 22 cmH2O; p = 0.11, respectively). PTX/PM patients had a higher odds of mortality (adjusted odds ratio [95%CI]: 3.37 [1.61-7.07]) and longer mean LOS (percent change [95%CI]: 39 [9-77]) than controls.
UNASSIGNED: In COVID-19 patients with similar severity, PTX/PM patients had more underlying lung disease and lower BMI. They had significantly increased mortality and LOS.
■对2020年03月1日至2022年01月在五家梅奥诊所住院的患有COVID-19的成年人进行了评估。PTX/PM通过成像确定。描述性分析和匹配的(年龄,性别,入学月,进行COVID-19严重程度)队列比较。医院死亡率,停留时间(LOS)并评估了诱发因素。
■在6663名患者中,197有PTX/PM(3%)(75PM,40PTX,82两者)。中位年龄为59岁,男性占71%。PTX/PM前有创和无创机械通气和高流量鼻插管的暴露率为42%,17%,20%,分别。在孤立的PTX和PM/PTX患者中,70%和53.7%接受了干预,分别,而仅PM组的96%被保守跟踪。将171名PTX/PM患者与171名匹配的对照进行比较。PTX/PM患者有更多的潜在肺部疾病(40.9与23.4%,p<0.001)和较低的中位体重指数(BMI)(29.5vs.31.3kg/m2,p=.007)比对照。在有可用数据的患者中,PTX/PM患者的呼气末正压和平台压中位数高于对照组;然而,差异不显著(10vs.8cmH2O;p=0.38和28vs.22cmH2O;分别为p=0.11)。与对照组相比,PTX/PM患者的死亡率较高(调整后比值比[95CI]:3.37[1.61-7.07])和平均LOS较长(变化百分比[95CI]:39[9-77])。
■在严重程度相似的COVID-19患者中,PTX/PM患者有更多的潜在肺部疾病和更低的BMI。他们的死亡率和LOS显着增加。