PDF(Pubmed)
Abstract：
UNASSIGNED: Behçet\'s disease is a chronic, multisystemic, and relapsing inflammatory disorder. It lacks a permanent cure, the focus of treatment is on mitigating symptoms, decreasing the frequency and severity of relapses, and preventing life-threatening complications. This study aims to report the experience of a single center in managing patients with Behçet\'s disease and discuss the treatment outcomes.
UNASSIGNED: This study was a retrospective case series conducted over 2 years. All cases were clinically diagnosed according to the International Criteria for Behçet\'s Disease. The extracted data were demographics, family history, clinical findings, criteria scores, treatment, and outcomes.
UNASSIGNED: A total of 31 patients were included, consisting of 13 males (42%) and 18 females (58%). Most cases were over the age of 30, and both genders were nearly equally distributed among age groups. The most commonly affected site was the oral cavity, observed in 96.77% of cases. Genital, cutaneous, and vascular involvements were more common in males, while females were more likely to have oral, ocular, and musculoskeletal involvements. For various treatment regimens, oral, cutaneous, vascular, and musculoskeletal involvements showed complete response in all cases. Among cases with genital involvement, complete response was achieved in seven cases (41.2%), while four cases (23.5%) showed only partial response, and six cases (35.3%) experienced recurrence. In cases with ocular involvement, only partial responses were observed.
UNASSIGNED: Oral, cutaneous, vascular, and musculoskeletal involvements may have a higher likelihood of a complete response to treatment regimens. However, genital involvement may be the most recurrent manifestation, followed by ocular involvement.
UNASSIGNED: This study was a retrospective case series conducted over 2 years. All cases were clinically diagnosed according to the International Criteria for Behçet\'s Disease. The extracted data were demographics, family history, clinical findings, criteria scores, treatment, and outcomes.
UNASSIGNED: A total of 31 patients were included, consisting of 13 males (42%) and 18 females (58%). Most cases were over the age of 30, and both genders were nearly equally distributed among age groups. The most commonly affected site was the oral cavity, observed in 96.77% of cases. Genital, cutaneous, and vascular involvements were more common in males, while females were more likely to have oral, ocular, and musculoskeletal involvements. For various treatment regimens, oral, cutaneous, vascular, and musculoskeletal involvements showed complete response in all cases. Among cases with genital involvement, complete response was achieved in seven cases (41.2%), while four cases (23.5%) showed only partial response, and six cases (35.3%) experienced recurrence. In cases with ocular involvement, only partial responses were observed.
UNASSIGNED: Oral, cutaneous, vascular, and musculoskeletal involvements may have a higher likelihood of a complete response to treatment regimens. However, genital involvement may be the most recurrent manifestation, followed by ocular involvement.
摘要：
■Behçet的疾病是一种慢性疾病，多系统，和复发性炎症性疾病。它缺乏永久的治疗方法，治疗的重点是减轻症状，降低复发的频率和严重程度，预防危及生命的并发症。本研究旨在报告单个中心管理Behçet病患者的经验，并讨论治疗结果。
■本研究是一个回顾性病例系列，历时2年。所有病例均根据国际白塞病标准进行临床诊断。提取的数据是人口统计，家族史,临床发现，标准分数，治疗,和结果。
■共包括31名患者，由13名男性(42%)和18名女性(58%)组成。大多数病例年龄在30岁以上，两种性别在年龄组中的分布几乎相等。最常见的受影响的部位是口腔，在96.77%的病例中观察到。生殖器,皮肤,血管受累在男性中更为常见，虽然女性更有可能口服，眼,和肌肉骨骼受累。对于各种治疗方案，口服,皮肤,血管,在所有情况下，肌肉骨骼受累均表现出完全反应。在生殖器受累的病例中，7例(41.2%)达到完全缓解，而4例(23.5%)仅部分缓解,6例(35.3%)复发。在眼部受累的情况下，仅观察到部分反应。
■口头，皮肤,血管,肌肉骨骼受累可能对治疗方案有更高的完全反应的可能性。然而,生殖器受累可能是最常见的表现，其次是眼部受累。
■本研究是一个回顾性病例系列，历时2年。所有病例均根据国际白塞病标准进行临床诊断。提取的数据是人口统计，家族史,临床发现，标准分数，治疗,和结果。
■共包括31名患者，由13名男性(42%)和18名女性(58%)组成。大多数病例年龄在30岁以上，两种性别在年龄组中的分布几乎相等。最常见的受影响的部位是口腔，在96.77%的病例中观察到。生殖器,皮肤,血管受累在男性中更为常见，虽然女性更有可能口服，眼,和肌肉骨骼受累。对于各种治疗方案，口服,皮肤,血管,在所有情况下，肌肉骨骼受累均表现出完全反应。在生殖器受累的病例中，7例(41.2%)达到完全缓解，而4例(23.5%)仅部分缓解,6例(35.3%)复发。在眼部受累的情况下，仅观察到部分反应。
■口头，皮肤,血管,肌肉骨骼受累可能对治疗方案有更高的完全反应的可能性。然而,生殖器受累可能是最常见的表现，其次是眼部受累。
