PDF(Pubmed)
Abstract：
Aging is classically associated with a decline of cognitive abilities, especially in relation to memory. While the development of potential treatments for neurodegenerative diseases has been in sharp focus, mild cognitive impairment (MCI), a form of age-related memory loss, in the absence of severe functional impairment, a condition experienced by many healthy adults, has received relatively little attention. Advances in this space would make significant contributions to the goal of healthy aging and may also help promote cognitive performance across the wider population. The individual action of either fructooligosaccharide (FOS) or L-theanine, both natural plant-derived molecules, has been tentatively linked with improvements in cognition, but our understanding remains far from complete. We therefore determined the effect of different dose combinations of FOS and L-theanine (termed MT-01/GBL-Memory1) in mice against FOS and L-theanine monotherapy. FOS and L-theanine were found to synergistically enhance murine memory in our animal tests at a dose of 100 mg/kg (coefficient of drug interaction (CDI) < 1). In a subsequent human trial, we demonstrated that MT-01 improved the memory of healthy adults after 1 month of consumption. Our results suggest that a combination of FOS and L-theanine synergistically enhances murine memory within a specific dose range. We show that this plant natural product regimen also improves human memory in a population of healthy adults. MT-01 therefore represents a novel, safe, and effective dietary supplement to promote human memory and cognition.
摘要：
衰老通常与认知能力的下降有关，尤其是关于记忆。虽然神经退行性疾病的潜在治疗方法的发展一直是人们关注的焦点，轻度认知障碍（MCI），一种与年龄有关的记忆丧失,在没有严重功能障碍的情况下，许多健康成年人都经历过这种情况，受到的关注相对较少。这一领域的进步将为健康老龄化的目标做出重大贡献，也可能有助于促进更广泛人群的认知表现。低聚果糖（FOS）或L-茶氨酸的单独作用，都是天然的植物衍生分子，已经初步与认知的改善联系在一起，但是我们的理解还远远没有完成。因此,我们确定了FOS和L-茶氨酸的不同剂量组合(称为MT-01/GBL-Memory1)在小鼠中针对FOS和L-茶氨酸单一疗法的作用。在我们的动物试验中,发现FOS和L-茶氨酸以100mg/kg的剂量协同增强鼠记忆(药物相互作用系数(CDI)<1)。在随后的人体试验中,我们证明,MT-01可改善健康成人在服用1个月后的记忆力.我们的结果表明，FOS和L-茶氨酸的组合在特定剂量范围内协同增强了小鼠的记忆。我们表明，这种植物天然产品方案还可以改善健康成年人群体的人类记忆力。因此，MT-01代表了一种小说，安全,和有效的膳食补充剂，以促进人类的记忆和认知。
