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Abstract：
UNASSIGNED: The aim of this study was to evaluate the therapeutic implications of acupuncture on improving ovarian function in women diagnosed with premature ovarian insufficiency (POI) through the implementation of randomized clinical trials (RCTs).
UNASSIGNED: A comprehensive search of eight databases was conducted to identify RCTs up until 5 October 2023. The outcomes included the levels of sex hormones, antral follicle count (AFC), Kupperman score, and total effective rate. The risk of bias (RoB) tool was utilized to evaluate the quality of the included studies. In order to guarantee the robustness and reliability of the findings, subgroup and sensitivity analyses were performed to investigate potential sources of heterogeneity.
UNASSIGNED: A total of 13 RCTs comprising 775 patients were included in the study. Acupuncture demonstrated significant efficacy in reducing follicle-stimulating hormone (FSH) [SMD = 0.83, 95% CI (0.27, 1.39), I 2 = 92%, p = 0.004], enhancing estradiol levels (E2) [SMD = 0.50, 95% CI (0.07, 0.93), p = 0.02, I 2 = 87%], and increasing anti-Müllerian hormone (AMH) [SMD = 0.24, 95% CI (0.05, 0.44), p = 0.01, I 2 = 8%], as well as improving the overall effective rate [RR = 1.22, 95% CI (1.10, 1.35), p < 0.01, I 2 = 14%]. Subgroup analysis revealed that compared with non-acupuncture therapy, the acupuncture with Chinese herbal medicine (CHM) and hormone replacement therapy (HRT) group exhibited a substantial reduction in FSH levels [SMD = 1.02, 95% CI (0.52, 1.51), I 2 = 60%, p < 0.01]. Furthermore, the acupuncture with CHM group also exhibited a substantial reduction [SMD = 4.59, 95% CI (1.53, 7.65), I 2 = 98%, p < 0.01]. However, only the acupuncture with CHM and HRT group demonstrated a significant increase in E2 levels [SMD = 0.55, 95% CI (0.23, 0.87), I 2 = 12%, p < 0.01].
UNASSIGNED: Acupuncture has demonstrated superiority over non-acupuncture in diminishing serum FSH levels and increasing serum E2, AMH, and the overall efficacy rate in women diagnosed with POI. These research findings suggest the necessity for broader-scale research with meticulous designs to fully demonstrate the efficacy and safety of acupuncture in the treatment of women with POI.
UNASSIGNED: https://www.crd.york.ac.uk, identifier CRD42023467751.
UNASSIGNED: A comprehensive search of eight databases was conducted to identify RCTs up until 5 October 2023. The outcomes included the levels of sex hormones, antral follicle count (AFC), Kupperman score, and total effective rate. The risk of bias (RoB) tool was utilized to evaluate the quality of the included studies. In order to guarantee the robustness and reliability of the findings, subgroup and sensitivity analyses were performed to investigate potential sources of heterogeneity.
UNASSIGNED: A total of 13 RCTs comprising 775 patients were included in the study. Acupuncture demonstrated significant efficacy in reducing follicle-stimulating hormone (FSH) [SMD = 0.83, 95% CI (0.27, 1.39), I 2 = 92%, p = 0.004], enhancing estradiol levels (E2) [SMD = 0.50, 95% CI (0.07, 0.93), p = 0.02, I 2 = 87%], and increasing anti-Müllerian hormone (AMH) [SMD = 0.24, 95% CI (0.05, 0.44), p = 0.01, I 2 = 8%], as well as improving the overall effective rate [RR = 1.22, 95% CI (1.10, 1.35), p < 0.01, I 2 = 14%]. Subgroup analysis revealed that compared with non-acupuncture therapy, the acupuncture with Chinese herbal medicine (CHM) and hormone replacement therapy (HRT) group exhibited a substantial reduction in FSH levels [SMD = 1.02, 95% CI (0.52, 1.51), I 2 = 60%, p < 0.01]. Furthermore, the acupuncture with CHM group also exhibited a substantial reduction [SMD = 4.59, 95% CI (1.53, 7.65), I 2 = 98%, p < 0.01]. However, only the acupuncture with CHM and HRT group demonstrated a significant increase in E2 levels [SMD = 0.55, 95% CI (0.23, 0.87), I 2 = 12%, p < 0.01].
UNASSIGNED: Acupuncture has demonstrated superiority over non-acupuncture in diminishing serum FSH levels and increasing serum E2, AMH, and the overall efficacy rate in women diagnosed with POI. These research findings suggest the necessity for broader-scale research with meticulous designs to fully demonstrate the efficacy and safety of acupuncture in the treatment of women with POI.
UNASSIGNED: https://www.crd.york.ac.uk, identifier CRD42023467751.
摘要：
■这项研究的目的是通过实施随机临床试验（RCTs）评估针灸改善诊断为卵巢早衰（POI）的女性卵巢功能的治疗意义。
■对8个数据库进行了全面搜索，以确定截至2023年10月5日的RCT。结果包括性激素水平，窦卵泡计数（AFC），Kupperman得分,和总有效率。使用偏倚风险（RoB）工具评估纳入研究的质量。为了保证研究结果的健壮性和可靠性,我们进行了亚组和敏感性分析,以调查异质性的潜在来源.
■本研究共纳入13个RCTs，包括775名患者。针刺在降低卵泡刺激素（FSH）方面具有显着的功效[SMD=0.83，95％CI（0.27，1.39），I2=92%，p=0.004],提高雌二醇水平（E2）[SMD=0.50，95%CI（0.07，0.93），p=0.02，I2=87%]，并增加抗苗勒管激素（AMH）[SMD=0.24，95％CI（0.05，0.44），p=0.01，I2=8%]，以及提高总有效率[RR=1.22，95%CI(1.10，1.35)，p<0.01，I2=14%]。亚组分析显示，与非针灸疗法相比，中草药针灸（CHM）和激素替代疗法（HRT）组显示FSH水平显着降低[SMD=1.02，95％CI（0.52，1.51），I2=60%,p<0.01]。此外，针刺与CHM组也表现出显著降低[SMD=4.59,95%CI(1.53,7.65),I2=98%，p<0.01]。然而,只有CHM和HRT组的针灸显示E2水平显着增加[SMD=0.55，95％CI（0.23，0.87），I2=12%，p<0.01]。
■针灸在降低血清FSH水平和增加血清E2，AMH，以及诊断为POI的女性的总体有效率。这些研究结果表明，有必要进行更广泛的研究，并进行精心设计，以充分证明针灸治疗POI女性的有效性和安全性。
■https://www.crd.约克。AC.英国，标识符CRD42023467751。
■对8个数据库进行了全面搜索，以确定截至2023年10月5日的RCT。结果包括性激素水平，窦卵泡计数（AFC），Kupperman得分,和总有效率。使用偏倚风险（RoB）工具评估纳入研究的质量。为了保证研究结果的健壮性和可靠性,我们进行了亚组和敏感性分析,以调查异质性的潜在来源.
■本研究共纳入13个RCTs，包括775名患者。针刺在降低卵泡刺激素（FSH）方面具有显着的功效[SMD=0.83，95％CI（0.27，1.39），I2=92%，p=0.004],提高雌二醇水平（E2）[SMD=0.50，95%CI（0.07，0.93），p=0.02，I2=87%]，并增加抗苗勒管激素（AMH）[SMD=0.24，95％CI（0.05，0.44），p=0.01，I2=8%]，以及提高总有效率[RR=1.22，95%CI(1.10，1.35)，p<0.01，I2=14%]。亚组分析显示，与非针灸疗法相比，中草药针灸（CHM）和激素替代疗法（HRT）组显示FSH水平显着降低[SMD=1.02，95％CI（0.52，1.51），I2=60%,p<0.01]。此外，针刺与CHM组也表现出显著降低[SMD=4.59,95%CI(1.53,7.65),I2=98%，p<0.01]。然而,只有CHM和HRT组的针灸显示E2水平显着增加[SMD=0.55，95％CI（0.23，0.87），I2=12%，p<0.01]。
■针灸在降低血清FSH水平和增加血清E2，AMH，以及诊断为POI的女性的总体有效率。这些研究结果表明，有必要进行更广泛的研究，并进行精心设计，以充分证明针灸治疗POI女性的有效性和安全性。
■https://www.crd.约克。AC.英国，标识符CRD42023467751。
