PDF(Pubmed)
Abstract：
Successful cognitive aging is often thought to result from resistance to the accumulation of pathology, resilience to the effects of pathological accumulation, or some combination of the two. While evidence for resilience has been found in typical aging populations, the oldest-old provide us with a unique window into the role of pathological accumulation in impacting cognition. Here, we aimed to assess group differences in measures of amyloid and tau across older age groups using data from the Alzheimer\'s Disease Neuroimaging Initiative (ADNI age: 60-89) and The 90+ Study (age: 90-101). Additionally, using the ADNI dataset, we performed exploratory analyses of regional cingulate AV-45 SUVRs to assess if amyloid load in particular areas was associated with Top Cognitive Performance (TCP). Consistent with the literature, results showed no group differences in amyloid SUVRs both regionally and in the whole cortex. For tau with AV-1451, we also observed no differences in Braak composite SUVRs. Interestingly, these relationships persisted in the oldest-old. This indicates that Top Cognitive Performance throughout aging does not reflect resistance to amyloid and tau burden, but that other mechanisms may be associated with protection against amyloid and tau related neurodegeneration.
摘要：
成功的认知衰老通常被认为是对病理积累的抵抗的结果，抵御病理性积累的影响，或者两者的某种组合。虽然在典型的老龄化人群中发现了韧性的证据，最古老的老人为我们提供了一个独特的窗口，了解病理积累在影响认知中的作用。这里,我们旨在利用阿尔茨海默病神经影像学计划(ADNI年龄:60-89岁)和90+研究(年龄:90-101岁)的数据,评估老年组淀粉样蛋白和tau指标的组间差异.此外,使用ADNI数据集，我们对区域扣带AV-45SUVR进行了探索性分析,以评估特定区域的淀粉样蛋白负荷是否与顶级认知表现(TCP)相关.与文献一致，结果表明，淀粉样蛋白SUVR在区域和整个皮质中都没有组间差异。对于具有AV-1451的tau,我们还观察到Braak复合SUVR没有差异。有趣的是,这些关系一直存在于最古老的时代。这表明，在整个衰老过程中，最高认知表现并不反映对淀粉样蛋白和tau负担的抵抗力，但其他机制可能与防止淀粉样蛋白和tau蛋白相关的神经变性有关。
