PDF(Pubmed)
Abstract：
UNASSIGNED: The pathophysiology and susceptibility of children to primary immune thrombocytopenia (ITP) are linked to polymorphisms of the interleukin (IL)-1B and IL-1 receptor (IL-1R) antagonist genes.
OBJECTIVE: To investigate the association between the susceptibility and severity of primary ITP in children and the IL-1B and IL-1R antagonist gene polymorphisms.
METHODS: This comparative case-control study was conducted at the Menoufia University Hospital Hematology and Oncology Unit, Pediatric Department, between August 2022 and September 2023. The children were divided into patients (28 boys, 22 girls) who received hospital and outpatient clinic care and controls (50 healthy age- and sex-matched children).
RESULTS: The mutant homozygous GG genotype and mutant G allele of rs16944 of the IL1B gene were considerably greater in patients than in controls (P<0.001). Furthermore, the mutant homozygous II/II genotype and heterozygous I/II genotype of the IL-1R antagonist gene were considerably greater in the case versus control group. The mutant II allele was significantly more prevalent in patients versus controls (P<0.001).
CONCLUSIONS: IL-1B and IL-1R antagonists may have a major impact on the development of immune thrombocytopenia. Furthermore, we found a relationship between IL-1B and IL-1R antagonist gene polymorphisms and the etiology of and children\'s susceptibility to primary immune thrombocytopenia.
OBJECTIVE: To investigate the association between the susceptibility and severity of primary ITP in children and the IL-1B and IL-1R antagonist gene polymorphisms.
METHODS: This comparative case-control study was conducted at the Menoufia University Hospital Hematology and Oncology Unit, Pediatric Department, between August 2022 and September 2023. The children were divided into patients (28 boys, 22 girls) who received hospital and outpatient clinic care and controls (50 healthy age- and sex-matched children).
RESULTS: The mutant homozygous GG genotype and mutant G allele of rs16944 of the IL1B gene were considerably greater in patients than in controls (P<0.001). Furthermore, the mutant homozygous II/II genotype and heterozygous I/II genotype of the IL-1R antagonist gene were considerably greater in the case versus control group. The mutant II allele was significantly more prevalent in patients versus controls (P<0.001).
CONCLUSIONS: IL-1B and IL-1R antagonists may have a major impact on the development of immune thrombocytopenia. Furthermore, we found a relationship between IL-1B and IL-1R antagonist gene polymorphisms and the etiology of and children\'s susceptibility to primary immune thrombocytopenia.
摘要：
■儿童对原发性免疫性血小板减少症的病理生理学和易感性与白细胞介素（IL）-1B和IL-1受体（IL-1R）拮抗剂基因的多态性有关。
■研究儿童原发性ITP的易感性和严重程度与IL-1B和IL-1R拮抗剂基因多态性之间的关系。
这项比较病例对照研究是在梅诺菲亚大学医院血液和肿瘤科进行的，儿科，2022年至2023年9月之间。孩子们被转移到病人身上(28名男孩，22名女孩）接受医院和门诊治疗和控制（50名年龄和性别匹配的健康儿童）。
■IL1B基因rs16944的突变纯合GG基因型和突变G等位基因在患者中明显高于对照组（P<0.001）。此外，与对照组相比,病例组IL-1R拮抗剂基因的突变型纯合II/II基因型和杂合I/II基因型显著更大.与对照组相比，突变II等位基因在患者中明显更普遍（P<0.001）。
■IL-1B和IL-1R拮抗剂可能对免疫性血栓-血细胞减少症的发展产生重大影响。此外，我们发现IL-1B和IL-1R拮抗剂基因多态性与儿童的病因之间存在关系。
■研究儿童原发性ITP的易感性和严重程度与IL-1B和IL-1R拮抗剂基因多态性之间的关系。
这项比较病例对照研究是在梅诺菲亚大学医院血液和肿瘤科进行的，儿科，2022年至2023年9月之间。孩子们被转移到病人身上(28名男孩，22名女孩）接受医院和门诊治疗和控制（50名年龄和性别匹配的健康儿童）。
■IL1B基因rs16944的突变纯合GG基因型和突变G等位基因在患者中明显高于对照组（P<0.001）。此外，与对照组相比,病例组IL-1R拮抗剂基因的突变型纯合II/II基因型和杂合I/II基因型显著更大.与对照组相比，突变II等位基因在患者中明显更普遍（P<0.001）。
■IL-1B和IL-1R拮抗剂可能对免疫性血栓-血细胞减少症的发展产生重大影响。此外，我们发现IL-1B和IL-1R拮抗剂基因多态性与儿童的病因之间存在关系。
