Abstract:
Brain malformations represent a heterogeneous group of abnormalities of neural morphogenesis, often associated with aberrations of neuronal connectivity and brain volume. Prenatal detection of brain malformations requires a clear understanding of embryology and developmental morphology through the various stages of gestation. This expert panel review is written with the central aim of providing an easy-to-understand roadmap to improve prenatal detection and characterization of structural malformations based on the current understanding of normal and aberrant brain development. The utility of each available neuroimaging modality including prenatal multiplanar neurosonography, anatomical magnetic resonance imaging (MRI), and advanced MRI techniques, as well as further insights from post-mortem imaging have been highlighted for every developmental stage.
摘要:
脑畸形代表一组异质的神经形态发生异常,通常与神经元连接和脑容量的畸变有关。产前检测脑畸形需要在妊娠的各个阶段对胚胎学和发育形态学有清晰的了解。本专家小组审查的主要目的是提供一个易于理解的路线图,以根据当前对正常和异常大脑发育的理解来改善结构畸形的产前检测和表征。每个可用的神经成像模式的效用,包括产前多平面神经超声检查,解剖磁共振成像(MRI),先进的核磁共振技术,以及进一步的见解,从尸检成像已经突出了每个发育阶段。