Abstract：
A foxhound from a hunting kennel in the United Kingdom was euthanized after being hospitalized with progressive neurologic signs, including tremors, seizures, and obtunded mentation. No abnormalities were appreciated on gross postmortem examination. Histologically, severe meningoencephalomyelitis and mild neuritis of the brachial plexus were present. Molecular analysis of brain tissue detected louping ill virus. In addition, louping ill virus-specific antigens were detected in neurons within the brainstem, the entire length of the spinal cord, as well as in rare cells in the brachial plexus using immunohistochemistry. The genetic sequence of the virus appears most closely related to a previously detected virus in a dog from a similar geographic location in 2015. This is the first characterization of the inflammatory lesions and viral distribution of louping ill virus in a naturally infected dog within the spinal cord and brachial plexus.
摘要：
英国猎犬的猎犬在因进行性神经系统症状住院后被安乐死，包括震颤,癫痫发作,和迟钝的心理状态。总体验尸没有异常。组织学上,存在严重的脑膜脑脊髓炎和臂丛神经轻度神经炎。脑组织的分子分析检测到肺平病病毒。此外,在脑干内的神经元中检测到病毒特异性抗原，脊髓的整个长度，以及使用免疫组织化学在臂丛神经中的稀有细胞中。该病毒的遗传序列似乎与2015年在类似地理位置的狗中检测到的病毒最密切相关。这是自然感染的狗在脊髓和臂丛神经中的炎症病变和病毒分布的第一个特征。
