Abstract：
BACKGROUND: To compare the choroidal thickness (CT) and choroidal vascularity index (CVI) values in ocular rosacea (OR) patients across skin subtypes of the disease and healthy controls.
METHODS: This prospective study included 90 eyes of 90 mild-moderate OR patients with different skin subtypes (30 phymatous, 30 papulopustular and 30 erythematotelangiectatic) and 30 eyes of 30 age-gender matched healthy volunteers. After obtaining the enhanced depth imaging optical coherence tomography images, the CT was measured at subfoveal, 1500μm nasal and 1500μm temporal to the fovea, and the CVI was calculated using Image J software in the subfoveal, nasal and temporal areas.
RESULTS: There was no CT significant difference between OR patients and healthy controls in all regions (p>0.05). CVI values of OR patients were found to be significantly lower in the subfoveal, nasal and temporal regions compared to healthy controls (p=0.02, p=0.01, p=0.01, respectively). No CT difference was detected between the subtypes and healthy controls in all regions (p>0.05). Subfoveal-CVI was significantly lower in the phymatous subtype than the other subtypes and controls (p<0.05), while nasal and temporal-CVI were significantly lower in the phymatous and papulopustular subtypes than the erythematotelangiectatic subtype and controls.
CONCLUSIONS: Our study demonstrated no difference between rosacea skin types and healthy controls in terms of CT. Phymatous and papulopustular subtypes were more likely to be affected by chronic inflammation with having lower CVI in most of the regions. Further studies are needed to investigate the association of inflammatory factors with CVI in OR.
METHODS: This prospective study included 90 eyes of 90 mild-moderate OR patients with different skin subtypes (30 phymatous, 30 papulopustular and 30 erythematotelangiectatic) and 30 eyes of 30 age-gender matched healthy volunteers. After obtaining the enhanced depth imaging optical coherence tomography images, the CT was measured at subfoveal, 1500μm nasal and 1500μm temporal to the fovea, and the CVI was calculated using Image J software in the subfoveal, nasal and temporal areas.
RESULTS: There was no CT significant difference between OR patients and healthy controls in all regions (p>0.05). CVI values of OR patients were found to be significantly lower in the subfoveal, nasal and temporal regions compared to healthy controls (p=0.02, p=0.01, p=0.01, respectively). No CT difference was detected between the subtypes and healthy controls in all regions (p>0.05). Subfoveal-CVI was significantly lower in the phymatous subtype than the other subtypes and controls (p<0.05), while nasal and temporal-CVI were significantly lower in the phymatous and papulopustular subtypes than the erythematotelangiectatic subtype and controls.
CONCLUSIONS: Our study demonstrated no difference between rosacea skin types and healthy controls in terms of CT. Phymatous and papulopustular subtypes were more likely to be affected by chronic inflammation with having lower CVI in most of the regions. Further studies are needed to investigate the association of inflammatory factors with CVI in OR.
摘要：
背景：目的比较眼部红斑痤疮（OR）患者的脉络膜厚度（CT）和脉络膜血管指数（CVI）在疾病和健康对照的皮肤亚型之间的值。
方法：这项前瞻性研究包括90例不同皮肤亚型的轻-中度OR患者的90只眼（30例，30名丘疹脓疱和30名红斑血管扩张）和30名年龄-性别匹配的健康志愿者的30只眼。获得增强后的深度成像光学相干层析成像图像,CT是在中心凹下测量的，1500μm鼻部和1500μm颞部至中央凹,使用ImageJ软件在中心凹下计算CVI，鼻腔和颞区。
结果：在所有地区，OR患者和健康对照组之间的CT没有显着差异（p>0.05）。发现OR患者的CVI值在中心凹下明显较低，与健康对照组相比，鼻腔和颞部区域（分别为p=0.02，p=0.01，p=0.01）。在所有地区，亚型和健康对照之间均未检测到CT差异（p>0.05）。中心凹下CVI显著低于其他亚型和对照(p<0.05),而肺部和丘疹脓疱亚型的鼻和颞叶CVI显着低于红斑血管扩张亚型和对照组。
结论：我们的研究表明，在CT方面，酒渣鼻皮肤类型和健康对照组之间没有差异。在大多数地区，植物性和丘疹脓疱亚型更容易受到慢性炎症的影响，CVI较低。炎症因子与CVI在OR中的相关性有待进一步研究。
方法：这项前瞻性研究包括90例不同皮肤亚型的轻-中度OR患者的90只眼（30例，30名丘疹脓疱和30名红斑血管扩张）和30名年龄-性别匹配的健康志愿者的30只眼。获得增强后的深度成像光学相干层析成像图像,CT是在中心凹下测量的，1500μm鼻部和1500μm颞部至中央凹,使用ImageJ软件在中心凹下计算CVI，鼻腔和颞区。
结果：在所有地区，OR患者和健康对照组之间的CT没有显着差异（p>0.05）。发现OR患者的CVI值在中心凹下明显较低，与健康对照组相比，鼻腔和颞部区域（分别为p=0.02，p=0.01，p=0.01）。在所有地区，亚型和健康对照之间均未检测到CT差异（p>0.05）。中心凹下CVI显著低于其他亚型和对照(p<0.05),而肺部和丘疹脓疱亚型的鼻和颞叶CVI显着低于红斑血管扩张亚型和对照组。
结论：我们的研究表明，在CT方面，酒渣鼻皮肤类型和健康对照组之间没有差异。在大多数地区，植物性和丘疹脓疱亚型更容易受到慢性炎症的影响，CVI较低。炎症因子与CVI在OR中的相关性有待进一步研究。
