Abstract：
Crustaceans such as shrimps and crabs, hold significant ecological significance and substantial economic value within marine ecosystems. However, their susceptibility to disease outbreaks and pathogenic infections has posed major challenges to production in recent decades. As invertebrate, crustaceans primarily rely on their innate immune system for defense, lacking the adaptive immune system found in vertebrates. Mucosal immunity, acting as the frontline defense against a myriad of pathogenic microorganisms, is a crucial aspect of their immune repertoire. This review synthesizes insights from comparative immunology, highlighting parallels between mucosal immunity in vertebrates and innate immune mechanisms in invertebrates. Despite lacking classical adaptive immunity, invertebrates, including crustaceans, exhibit immune memory and rely on inherent \"innate immunity factors\" to combat invading pathogens. Drawing on parallels from mammalian and piscine systems, this paper meticulously explores the complex role of mucosal immunity in regulating immune responses in crustaceans. Through the extrapolation from well-studied models like mammals and fish, this review infers the potential mechanisms of mucosal immunity in crustaceans and provides insights for research on mucosal immunity in crustaceans.
摘要：
甲壳类动物，如虾和蟹，在海洋生态系统中具有重要的生态意义和巨大的经济价值。然而,近几十年来，它们对疾病爆发和病原体感染的易感性对生产构成了重大挑战。作为无脊椎动物，甲壳类动物主要依靠先天免疫系统进行防御，缺乏脊椎动物的适应性免疫系统.黏膜免疫,作为抵御无数病原微生物的前线防御，是他们免疫库的一个关键方面。这篇综述综合了比较免疫学的见解，强调脊椎动物粘膜免疫和无脊椎动物先天免疫机制之间的相似之处。尽管缺乏经典的适应性免疫，无脊椎动物,包括甲壳类动物,表现出免疫记忆，并依靠固有的“先天免疫因子”来对抗入侵的病原体。利用哺乳动物和鱼系统的相似之处，本文详细探讨了粘膜免疫在调节甲壳类动物免疫反应中的复杂作用。通过从哺乳动物和鱼类等经过充分研究的模型中推断，这篇综述推断了甲壳类动物黏膜免疫的潜在机制，并为甲壳类动物黏膜免疫的研究提供了见解。
