Abstract：
BACKGROUND: Polycystic Ovary Syndrome (PCOS) is a hormonal disorder in women associated with increased cardiovascular risk. Cinnamon, a Chinese herbal medicine, is known for its anti-inflammatory and insulin-sensitizing properties, making it a potential therapeutic agent for PCOS-related cardiovascular complications. This systematic review and meta-analysis aimed to assess the impact of cinnamon supplementation on cardiovascular risk markers in women diagnosed with PCOS.
METHODS: Twelve randomized controlled trials (RCTs) were included in the analysis. The primary outcomes assessed were body weight, insulin resistance measured by Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), and fasting blood sugar (FBS).
RESULTS: The meta-analysis revealed a statistically significant effect of cinnamon on reducing weight. Under the random-effects model, the pooled weighted mean difference (WMD) was -0.47 kg (95 % CI: -0.80 to -0.15, p < 0.001; I2 = 0.0 %). There was also a beneficial impact on insulin resistance, with reduced HOMA-IR scores following cinnamon supplementation (SMD=0.5015, 95 % CI: 0.2496 to 0.7533, p < 0.0001). Additionally, there was a significant improvement in FBS levels (pooled WMD: -7.72 mg/dL, 95 % CI: -12.33 to -3.12, p < 0.001; I2 = 91.3 %). The meta-analysis indicated a tendency towards reduced total cholesterol (WMD: -11.12 mg/dL, 95 % CI: -19.06 to -3.18, p = 0.01; I2 = 0.0 %) and LDL levels (WMD: -11.11 mg/dL, 95 % CI: -18.22 to -4.00, p < 0.01; I2 = 0.0 %) following cinnamon intervention. Substantial heterogeneity was observed among the studies, indicating the need for further research with larger sample sizes and standardized methodologies.
CONCLUSIONS: Cinnamon supplementation demonstrates promising effects on body weight, blood sugar, total cholesterol, LDL, and insulin resistance in women with PCOS, indicating its potential in mitigating cardiovascular risk factors associated with this condition.
METHODS: Twelve randomized controlled trials (RCTs) were included in the analysis. The primary outcomes assessed were body weight, insulin resistance measured by Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), and fasting blood sugar (FBS).
RESULTS: The meta-analysis revealed a statistically significant effect of cinnamon on reducing weight. Under the random-effects model, the pooled weighted mean difference (WMD) was -0.47 kg (95 % CI: -0.80 to -0.15, p < 0.001; I2 = 0.0 %). There was also a beneficial impact on insulin resistance, with reduced HOMA-IR scores following cinnamon supplementation (SMD=0.5015, 95 % CI: 0.2496 to 0.7533, p < 0.0001). Additionally, there was a significant improvement in FBS levels (pooled WMD: -7.72 mg/dL, 95 % CI: -12.33 to -3.12, p < 0.001; I2 = 91.3 %). The meta-analysis indicated a tendency towards reduced total cholesterol (WMD: -11.12 mg/dL, 95 % CI: -19.06 to -3.18, p = 0.01; I2 = 0.0 %) and LDL levels (WMD: -11.11 mg/dL, 95 % CI: -18.22 to -4.00, p < 0.01; I2 = 0.0 %) following cinnamon intervention. Substantial heterogeneity was observed among the studies, indicating the need for further research with larger sample sizes and standardized methodologies.
CONCLUSIONS: Cinnamon supplementation demonstrates promising effects on body weight, blood sugar, total cholesterol, LDL, and insulin resistance in women with PCOS, indicating its potential in mitigating cardiovascular risk factors associated with this condition.
摘要：
背景：多囊卵巢综合征（PCOS）是一种与心血管风险增加相关的女性激素紊乱。肉桂,一种中草药，以其抗炎和胰岛素增敏特性而闻名，使其成为PCOS相关心血管并发症的潜在治疗剂。本系统评价和荟萃分析旨在评估肉桂补充剂对诊断为PCOS的女性心血管风险标志物的影响。
方法：12项随机对照试验（RCTs）纳入分析。评估的主要结果是体重，通过稳态胰岛素抵抗模型评估（HOMA-IR）测量胰岛素抵抗，空腹血糖（FBS）。
结果：荟萃分析显示肉桂对减轻体重具有统计学意义。在随机效应模型下，合并加权平均差(WMD)为-0.47kg(95%CI:-0.80~-0.15,p<0.001;I2=0.0%).对胰岛素抵抗也有有益的影响，补充肉桂后HOMA-IR评分降低（SMD=0.5015，95%CI：0.2496至0.7533，p<0.0001）。此外,FBS水平有显著改善(合并WMD：-7.72mg/dL，95%CI：-12.33至-3.12，p<0.001；I2=91.3%）。荟萃分析表明总胆固醇降低的趋势（大规模杀伤性疾病：-11.12mg/dL，95％CI：-19.06至-3.18，p=0.01；I2=0.0％）和LDL水平（WMD：-11.11mg/dL，95%CI：-18.22至-4.00，p<0.01；I2=0.0%）肉桂干预后。在研究中观察到实质性的异质性，这表明需要用更大的样本量和标准化的方法进行进一步的研究。
结论：肉桂补充剂对体重具有良好的效果，血糖,总胆固醇,LDL,和PCOS女性的胰岛素抵抗，表明其在减轻与这种情况相关的心血管危险因素方面的潜力。
方法：12项随机对照试验（RCTs）纳入分析。评估的主要结果是体重，通过稳态胰岛素抵抗模型评估（HOMA-IR）测量胰岛素抵抗，空腹血糖（FBS）。
结果：荟萃分析显示肉桂对减轻体重具有统计学意义。在随机效应模型下，合并加权平均差(WMD)为-0.47kg(95%CI:-0.80~-0.15,p<0.001;I2=0.0%).对胰岛素抵抗也有有益的影响，补充肉桂后HOMA-IR评分降低（SMD=0.5015，95%CI：0.2496至0.7533，p<0.0001）。此外,FBS水平有显著改善(合并WMD：-7.72mg/dL，95%CI：-12.33至-3.12，p<0.001；I2=91.3%）。荟萃分析表明总胆固醇降低的趋势（大规模杀伤性疾病：-11.12mg/dL，95％CI：-19.06至-3.18，p=0.01；I2=0.0％）和LDL水平（WMD：-11.11mg/dL，95%CI：-18.22至-4.00，p<0.01；I2=0.0%）肉桂干预后。在研究中观察到实质性的异质性，这表明需要用更大的样本量和标准化的方法进行进一步的研究。
结论：肉桂补充剂对体重具有良好的效果，血糖,总胆固醇,LDL,和PCOS女性的胰岛素抵抗，表明其在减轻与这种情况相关的心血管危险因素方面的潜力。
