Abstract：
Biological environments present a complex array of metal-binding ligands. Metal-binding proteins have been the overwhelming focus of study because of their important and well-defined biological roles. Consequently, the presence of functional low molecular weight (LMW) metal-ligand complexes has been overlooked in terms of their roles in metallobiochemistry, particularly within cells. Recent studies in microbial systems have illuminated the different roles of L-histidine in nickel uptake, gene expression, and metalloenzyme maturation. In this focused critical review, these roles are surveyed in the context of the coordination chemistry of Ni(II) ions and the amino acid histidine, and the physico-chemical properties of nickel complexes of histidine. These complexes are fundamentally important to cellular metal homeostasis and further work is needed to fully define their contributions.
摘要：
生物环境呈现金属结合配体的复杂阵列。金属结合蛋白由于其重要和明确的生物学作用而成为研究的焦点。因此,功能性低分子量(LMW)金属-配体配合物的存在在金属生物化学中的作用方面被忽视,特别是在细胞内。微生物系统的最新研究阐明了L-组氨酸在镍吸收中的不同作用，基因表达，和金属酶成熟。在这次重点审查中，这些作用是在Ni（II）离子和氨基酸组氨酸的配位化学的背景下进行调查的，组氨酸镍配合物的理化性质。这些配合物对细胞金属稳态至关重要，需要进一步的工作来充分定义它们的贡献。
