Abstract：
Background: To investigate the predictive value of preoperative peripheral blood inflammatory markers for surgical site infection (SSI) in laparoscopic radical gastrectomy for gastric cancer. Methods: A retrospective analysis was conducted on patients undergoing laparoscopic radical gastrectomy for gastric cancer, categorized into SSI and non-SSI groups based on postoperative SSI occurrences. Patient demographics, surgical details, laboratory results, and SSI incidence data were extracted. Differences in indicators, including neutrophil-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), and platelet-lymphocyte ratio (PLR), were assessed between the two groups. Multivariate logistic regression was utilized to determine the independent association of each indicator with SSI. Receiver operating characteristics (ROC) curve analysis was utilized to evaluate the predictive value of parameters. Results: Of 169 patients, 36 (21.30%) experienced SSI postoperatively. The SSI group exhibited higher preoperative NLR and SII (p < 0.05). After adjusting for variables, preoperative NLR (OR = 1.691, 95% CI: 1.211-2.417, p = 0.003) and SII (OR = 1.001, 95% CI: 1.000-1.002, p = 0.006) were identified as independent risk factors for SSI. Both NLR (AUC = 0.758, 95% CI: 0.666-0.850) and SII (AUC = 0.753, 95% CI: 0.660-0.850) demonstrated favorable diagnostic performance for predicting postoperative SSI. Conclusion: Preoperative NLR and SII significantly associate with postoperative SSI in laparoscopic radical gastrectomy for gastric cancer, making them valuable indicators for early prediction of SSI.
摘要：
背景:探讨术前外周血炎性标志物对腹腔镜胃癌根治术手术部位感染(SSI)的预测价值。方法:回顾性分析腹腔镜胃癌根治术患者,根据术后SSI发生情况分为SSI和非SSI组。患者人口统计学，手术细节,实验室结果,并提取SSI发生率数据。指标差异,包括中性粒细胞-淋巴细胞比率（NLR），全身免疫炎症指数（SII），和血小板淋巴细胞比率（PLR），在两组之间进行评估。采用多因素logistic回归分析各指标与SSI的独立关联。利用受试者工作特征（ROC）曲线分析来评估参数的预测值。结果：169例患者中，36例（21.30%）患者术后发生SSI。SSI组术前NLR和SII较高(p<0.05)。调整变量后，术前NLR(OR=1.691,95%CI:1.211-2.417,p=0.003)和SII(OR=1.001,95%CI:1.000-1.002,p=0.006)为SSI的独立危险因素。NLR（AUC=0.758，95％CI：0.666-0.850）和SII（AUC=0.753，95％CI：0.660-0.850）均显示出预测术后SSI的良好诊断性能。结论:腹腔镜胃癌根治术术前NLR和SII与术后SSI显著相关,使它们成为早期预测SSI的有价值的指标。
