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Abstract：
Immune checkpoint inhibitors (ICIs) have significantly improved the clinical outcome in multiple types of advanced or metastatic malignancies and are prescribed increasingly. However, immune-related adverse events (irAEs) occur frequently. Here, we present a patient with multifocal motor neuropathy and melanoma, with worsening of muscle weakness upon ICI therapy and concomitant use of steroids for the treatment of hepatitis, which was considered an irAE. Upon treatment with highly dosed immunoglobulins and steroid tapering, the patients\' muscular symptoms improved while hepatitis resolved. This case highlights the importance of careful evaluation of patients with multifocal motor neuropathy treated with ICIs, highlights the risks of treatment with steroids in multifocal motor neuropathy patients and suggests an alternative treatment of irAEs with intravenous immunoglobulins.
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[Box: see text].
摘要：
免疫检查点抑制剂（ICIs）已经显著改善了多种类型的晚期或转移性恶性肿瘤的临床结果，并且越来越多地被处方。然而,免疫相关不良事件（irAE）经常发生。这里,我们介绍了一名多灶性运动神经病和黑色素瘤的患者，ICI治疗后肌肉无力恶化，同时使用类固醇治疗肝炎，这被认为是IRAE。在用高剂量的免疫球蛋白和类固醇逐渐减少治疗时，患者肌肉症状改善，而肝炎消退。该病例强调了仔细评估使用ICIs治疗的多灶性运动神经病患者的重要性。强调了多灶性运动神经病患者使用类固醇治疗的风险,并建议使用静脉注射免疫球蛋白替代治疗irAE.
[方框：见正文]。
[方框：见正文]。
