PDF(Pubmed)
Abstract：
A higher level of education was correlated with less severe motor impairment in Parkinson\'s Disease (PD). Nevertheless, there is limited evidence on the relationship between cognitive reserve and motor performance in complex situations in PD. To investigate the association between cognitive reserve and the dual-task gait effect in PD. Additionally, we examined the relationship between executive function, clinical and sociodemographic variables and, dual-task gait effects. We conducted a cross-sectional study with 44 PD participants. We evaluated dual-task effect on cadence, stride length, and gait velocity. Dual-task effects were correlated with neurophysiological factors, including cognitive reserve (Cognitive Reserve Index Questionnaire), overall cognitive performance of executive functions, a specific executive function domain (Trail Making Test), and the global cognitive status (Montreal Cognitive Assessment and Mini-Mental State Examination). Age, gender, and disease severity were considered as variables to be examined for correlation. We found that cognitive reserve did not influence gait performance under dual-task conditions in this sample. However, executive functions, age, and disease severity were associated with the dual-task effect on gait. The overall cognitive performance with respect to the Trail Making Test showed an inverse relationship in the dual-task gait effect on cadence. Our study\'s findings have important implications for understanding the association between executive functions, age, and disease severity with the dual-task effect on gait in PD. Pre-life factors, such as education, occupation, and leisure activity, did not contribute to coping with complex gait situations in PD.
摘要：
在帕金森病（PD）中，较高的教育水平与较轻的运动障碍相关。然而，关于PD中复杂情况下认知储备与运动表现之间关系的证据有限。探讨认知储备与PD双任务步态效应的关系。此外,我们研究了执行功能之间的关系，临床和社会人口统计学变量，双重任务步态效应。我们对44名PD参与者进行了横断面研究。我们评估了双任务对节奏的影响，步幅长度,和步态速度。双任务效应与神经生理因素相关，包括认知储备(认知储备指数问卷)，执行功能的整体认知表现，特定的执行功能域(跟踪测试)，和全球认知状况(蒙特利尔认知评估和简易精神状态检查)。年龄,性别,和疾病严重程度被认为是要检查相关性的变量。我们发现，在此样本中，在双重任务条件下，认知储备不会影响步态表现。然而,执行功能，年龄,疾病严重程度与双任务对步态的影响相关。相对于TrailMakingTest的整体认知表现在双任务步态对节奏的影响中呈反比关系。我们的研究结果对理解执行功能之间的关联具有重要意义。年龄,和疾病严重程度对PD步态的双重任务影响。生命前的因素，比如教育，职业,和休闲活动，无助于应对PD中复杂的步态情况。
