PDF(Pubmed)
Abstract：
Obesity is a big public health problem that claims several thousand lives every year. Bariatric surgery has arisen as a suitable procedure for treating obesity, particularly morbid obesity. Oxidative stress, genotoxicity, apoptosis, and inflammatory responses are recognized as the most important occurrences in carcinogenesis, as they actively contribute to the multistep process. This study aimed to briefly review the connection between oxidative stress, genotoxicity, apoptosis, and inflammation in obese patients undergoing bariatric surgery, focusing on its impact on carcinogenesis. Regarding oxidative stress, bariatric surgery may inhibit the synthesis of reactive oxygen species. Moreover, a significant reduction in the inflammatory status after weight loss surgery was not observed. Bariatric surgery prevents apoptosis in several tissues, but the maintenance of low body weight for long periods is mandatory for mitigating DNA damage. In conclusion, the association between bariatric surgery and cancer risk is still premature. However, further studies are yet needed to elucidate the real association between bariatric surgery and a reduced risk of cancer.
摘要：
肥胖是一个巨大的公共卫生问题，每年夺去数千人的生命。减肥手术已成为治疗肥胖症的合适方法，尤其是病态肥胖.氧化应激,遗传毒性，凋亡，炎症反应被认为是癌症发生中最重要的事件，因为他们积极为多步骤过程做出贡献。本研究旨在简要回顾氧化应激之间的联系，遗传毒性，凋亡，肥胖患者接受减肥手术的炎症，关注其对致癌作用的影响。关于氧化应激，减肥手术可能会抑制活性氧的合成。此外，未观察到减重手术后炎症状态的显著降低.减肥手术可防止几种组织的细胞凋亡，但是长期维持低体重对于减轻DNA损伤是强制性的。总之,减肥手术与癌症风险之间的联系尚不成熟.然而,还需要进一步的研究来阐明减重手术与降低癌症风险之间的真正关联.
